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Start Over Author "Katharina Poustka" Journal journal of neuroimmunology
1 results on '"Katharina Poustka"'

1. Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein depend on familial background and are partially associated with human leukocyte antigen alleles in multiplex families and sporadic multiple sclerosis

Author

Katharina Poustka, Markus Reindl, Thomas Berger, Andreas Lutterotti, Kathrin Schanda, Christoph Gassner, and F. Deisenhammer

Subjects
Adult, Male, Multiple Sclerosis, Genotype, Immunology, Genes, MHC Class II, Human leukocyte antigen, Myelin oligodendrocyte glycoprotein, Gene Frequency, immune system diseases, HLA-DQ Antigens, medicine, Immunology and Allergy, HLA-DQ beta-Chains, Humans, HLA-DRB1, Alleles, Autoantibodies, Family Health, biology, Myelin-associated glycoprotein, HLA-DQ Antigen, Multiple sclerosis, Autoantibody, hemic and immune systems, Myelin Basic Protein, HLA-DR Antigens, Middle Aged, medicine.disease, Virology, nervous system diseases, Myelin basic protein, Myelin-Associated Glycoprotein, nervous system, Neurology, biology.protein, Female, Myelin-Oligodendrocyte Glycoprotein, Neurology (clinical), Myelin Proteins
Abstract

We investigated the association of the antibody response to myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) with human leukocyte antigen (HLA) class II alleles in 41 patients with sporadic multiple sclerosis (MS) and 12 multiplex MS families. We found significantly increased antibody response to MOG and MBP in MS patients without any difference to asymptomatic relatives. HLA DRB1*04 was associated with IgM reactivity to MOG in MS patients, and DRB1*15 and DRB5 with anti-MOG IgA among asymptomatic relatives. We conclude that antibody responses to MOG and MBP depend on familial background. Moreover, the humoral immune reactivity against MOG is partially under control of certain HLA class II alleles.

Published
2002

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