1. Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.
- Author
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Lioy DT, Sheridan PA, Hurley SD, Walton JR, Martin AM, Olschowka JA, and Moynihan JA
- Subjects
- Animals, Ataxia etiology, Ataxia virology, Blood-Brain Barrier drug effects, Blood-Brain Barrier physiopathology, Blood-Brain Barrier virology, Brain drug effects, Brain pathology, Brain virology, Disease Models, Animal, Dose-Response Relationship, Drug, Herpesvirus 1, Human pathogenicity, Immunoglobulin G metabolism, Immunohistochemistry methods, Male, Mannitol pharmacology, Mice, Mice, Inbred BALB C, Paralysis etiology, Paralysis virology, RNA, Messenger biosynthesis, Reverse Transcriptase Polymerase Chain Reaction methods, Severity of Illness Index, Time Factors, Encephalitis etiology, Encephalitis virology, Herpesvirus 1, Human physiology, Morphine pharmacology, Narcotics pharmacology
- Abstract
A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the disease remain to be elucidated. The current study examined the effects of a single dose of morphine prior to infection with HSV-1 on the development of HSVE in BALB/cByJ mice. Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice.
- Published
- 2006
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