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Start Over Author "Rijs A" Journal journal of neuroimmunology
13 results on '"Rijs A"'

6. Mannosylated PLP139–151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis

Author

Jan W. Drijfhout, Wouter van Rijs, Mariken E. Luca, Lex Nagelkerken, Frits Koning, and Junda M. Kel

Subjects
Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Proteolipid protein 1, Injections, Subcutaneous, T cell, Molecular Sequence Data, Immunology, Biology, Severity of Illness Index, Mice, Cell Movement, medicine, Animals, Immunology and Allergy, Hypersensitivity, Delayed, Amino Acid Sequence, Myelin Proteolipid Protein, Cells, Cultured, Immunodominant Epitopes, Cell growth, Experimental autoimmune encephalomyelitis, Th1 Cells, medicine.disease, Peptide Fragments, Myelin proteolipid protein, Mononuclear cell infiltration, Self Tolerance, medicine.anatomical_structure, Neurology, Delayed hypersensitivity, Leukocytes, Mononuclear, Female, Neurology (clinical), Mannose, Mannose receptor
Abstract

SJL mice immunized with mannosylated (M-) PLP139-151 in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP139-151-immunized mice show impaired delayed-type-sensitivity to PLP139-151 but a normal response to other peptides. After re-immunization with PLP139-151 in complete adjuvant, these mice are largely tolerant to EAE, show less T cell proliferation and decreased peptide-specific IgG2a. Our data suggest that M-PLP139-151 induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells. © 2004 Elsevier B.V. All rights reserved. Chemicals / CAS: Immunodominant Epitopes; Mannose, 31103-86-3; Myelin Proteolipid Protein; Peptide Fragments; proteolipid protein 139-151

Published
2005
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7. Functional polymorphisms in LPS receptors CD14 and TLR4 are not associated with disease susceptibility or Campylobacter jejuni infection in Guillain-Barré patients

Author

Jon D. Laman, Anne P. Tio-Gillen, Pieter A. van Doorn, Wouter van Rijs, Karin Geleijns, Bart C. Jacobs, Neurology, and Immunology

Subjects
Adult, Male, Adolescent, Immunology, Lipopolysaccharide Receptors, Receptors, Cell Surface, Guillain-Barre Syndrome, Campylobacter jejuni, Polymorphism, Single Nucleotide, Serology, Disability Evaluation, Campylobacter Jejuni Infection, Gangliosides, Campylobacter Infections, Immunology and Allergy, Medicine, Humans, Genetic Predisposition to Disease, Serologic Tests, Child, Pathogen, Aged, Autoantibodies, Aged, 80 and over, Membrane Glycoproteins, Polymorphism, Genetic, biology, Guillain-Barre syndrome, business.industry, Toll-Like Receptors, Middle Aged, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Prognosis, Toll-Like Receptor 4, Neurology, TLR4, biology.protein, Female, Neurology (clinical), Antibody, business, Polyneuropathy, Signal Transduction
Abstract

Guillain-Barre syndrome (GBS) is an acute immune-mediated polyneuropathy preceded by infections. Campylobacter jejuni is the most frequent pathogen and its lipopolysaccharide (LPS) induces antibodies cross-reactive with gangliosides. In this study we assessed whether known functional polymorphisms in the LPS receptors CD14 and Toll-like receptor 4 (TLR4) are associated with an increased susceptibility for GBS or with C. jejuni serology or C. jejuni related clinical and serological features. Comparison of the genotypes of 242 GBS patients and 210 healthy subjects showed that polymorphisms in CD14 and TLR4 did not confer disease susceptibility and were not associated with C. jejuni infection.

Published
2004
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8. Susceptibility to Guillain–Barré syndrome is not associated with CD1A and CD1E gene polymorphisms

Author

Bart C. Jacobs, Noureddine Ennaji, Wouter van Rijs, Karin Geleijns, Pieter A. van Doorn, Mark L. Kuijf, Neurology, and Cardiology

Subjects
Adult, Male, Adolescent, Genotype, Immunology, Antigen presentation, Single-nucleotide polymorphism, Disease, Biology, Guillain-Barre Syndrome, Polymorphism, Single Nucleotide, Statistics, Nonparametric, Epitope, Antigens, CD1, Young Adult, Immune system, Gene Frequency, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Child, Gene, Aged, Aged, 80 and over, Genetics, Guillain-Barre syndrome, hemic and immune systems, Middle Aged, bacterial infections and mycoses, medicine.disease, Neurology, biology.protein, bacteria, Female, lipids (amino acids, peptides, and proteins), Neurology (clinical), Antibody
Abstract

Immune responses to microbial glycolipids that cross-react to neural epitopes may trigger the Guillain-Barr syndrome (GBS). CD1 molecules are involved in antigen presentation of glycolipids and variation in CD1 genes was recently reported to confer susceptibility to develop GBS. This hypothesis was tested by comparing single nucleotide polymorphisms (SNPs) of CD1A and CD1E in 312 well defined GBS patients and 212 healthy controls. SNPs in CD1A and CD1E were not associated with GBS Susceptibility, specific clinical Subgroups, anti-ganglioside antibodies. antecedent infections and prognosis. Based on this study, CD1 polymorphisms are not a susceptibility or disease modifying factor in GBS. (C) 2008 Elsevier B.V. All rights reserved.

Published
2008
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10. Enhanced innate immune activation by Guillain-Barré syndrome-associated Campylobacter jejuni lipo-oligosaccharides

Author

Janneke N. Samsom, Ruth Huizinga, Wouter van Rijs, Astrid P. Heikema, Jon D. Laman, Jeffrey J. Bajramovic, and Bart C. Jacobs

Subjects
Innate immune system, Guillain-Barre syndrome, biology, business.industry, Immunology, medicine.disease, biology.organism_classification, Campylobacter jejuni, Neurology, Immunology and Allergy, Medicine, Neurology (clinical), business
Published
2014
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13. Mannosylated PLP139–151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis

Author

Luca, Mariken E., Kel, Junda M., van Rijs, Wouter, Wouter Drijfhout, Jan, Koning, Frits, and Nagelkerken, Lex

Subjects
*CELLULAR mechanics, *CENTRAL nervous system diseases, *IMMUNOLOGICAL adjuvants, *PEPTIDES
Abstract

Abstract: SJL mice immunized with mannosylated (M-) PLP139–151 in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP139–151-immunized mice show impaired delayed-type-sensitivity to PLP139–151 but a normal response to other peptides. After re-immunization with PLP139–151 in complete adjuvant, these mice are largely tolerant to EAE, show less T cell proliferation and decreased peptide-specific IgG2a. Our data suggest that M-PLP139–151 induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells. [Copyright &y& Elsevier]

Published
2005
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