Search

Your search keyword '"Tbet"' showing total 2 results
Start Over Descriptor "Tbet" Journal journal of neuroimmunology
2 results on '"Tbet"'

1. IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms.

Author

Yeh, Wen-I, McWilliams, Ian L., and Harrington, Laurie E.

Subjects
*INTERLEUKIN-17, *T helper cells, *GENETIC transcription, *CELL differentiation, *CD4 antigen, *IMMUNOLOGICAL aspects of encephalomyelitis, *ENZYME inhibitors
Abstract

Abstract: The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. Moreover, we find that IFNγ inhibits the production of IL-17A and IL-17F in a STAT1-dependent, Tbet-independent manner. These findings illustrate multiple mechanisms utilized by developing Th1 cells to silence the Th17 program. [Copyright &y& Elsevier]

Published
2014
Full Text
View/download PDF

2. IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms

Author

Ian L. McWilliams, Laurie E. Harrington, and Wen-I Yeh

Subjects
Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Mice, 129 Strain, Cellular differentiation, Immunology, Mice, Transgenic, Biology, Article, Mice, In vivo, medicine, IL-17A, Immunology and Allergy, Animals, Transcription factor, Regulation of gene expression, Homeodomain Proteins, Experimental autoimmune encephalomyelitis, Interleukin-12 Subunit p40, Interleukins, Interleukin-17, Interleukin, Cell Polarity, Cell Differentiation, CD4 T cell, Nuclear Receptor Subfamily 1, Group F, Member 3, medicine.disease, In vitro, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, STAT1 Transcription Factor, Neurology, Gene Expression Regulation, CD4 Antigens, Leukocyte Common Antigens, Th17 Cells, Neurology (clinical), Interleukin 17, T-Box Domain Proteins, Tbet, IFNγ
Abstract

The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. Moreover, we find that IFNγ inhibits the production of IL-17A and IL-17F in a STAT1-dependent, Tbet-independent manner. These findings illustrate multiple mechanisms utilized by developing Th1 cells to silence the Th17 program.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results