1. Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy.
- Author
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Ferreira D, Voevodskaya O, Imrell K, Stawiarz L, Spulber G, Wahlund LO, Hillert J, Westman E, and Karrenbauer VD
- Subjects
- Adult, Atrophy cerebrospinal fluid, Atrophy immunology, Atrophy pathology, Brain immunology, Brain pathology, Brain Diseases cerebrospinal fluid, Brain Diseases pathology, Disability Evaluation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive cerebrospinal fluid, Multiple Sclerosis, Chronic Progressive pathology, Multiple Sclerosis, Relapsing-Remitting cerebrospinal fluid, Multiple Sclerosis, Relapsing-Remitting pathology, Multivariate Analysis, Oligoclonal Bands cerebrospinal fluid, Brain Diseases immunology, Multiple Sclerosis, Chronic Progressive immunology, Multiple Sclerosis, Relapsing-Remitting immunology, Oligoclonal Bands immunology
- Abstract
To investigate whether multiple sclerosis (MS) patients with and without cerebrospinal fluid (CSF) oligoclonal immunoglobulin G bands (OCB) differ in brain atrophy. Twenty-eight OCB-negative and thirty-five OCB-positive patients were included. Larger volumes of total CSF and white matter (WM) lesions; smaller gray matter (GM) volume in the basal ganglia, diencephalon, cerebellum, and hippocampus; and smaller WM volume in corpus callosum, periventricular-deep WM, brainstem, and cerebellum, were observed in OCB-positives. OCB-negative patients, known to differ genetically from OCB-positives, are characterized by less global and regional brain atrophy. This finding supports the notion that OCB-negative MS patients may represent a clinically relevant MS subgroup., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
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