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Start Over Author "Zaratin, P" Journal journal of neuroimmunology
3 results on '"Zaratin, P"'

3. Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies.

Author

Dati G, Quattrini A, Bernasconi L, Malaguti MC, Antonsson B, Nicoletti F, Alliod C, Di Marco R, Sagot Y, Vitte PA, Hiver A, Greco B, Roach A, and Zaratin PF

Subjects
Animals, Clusterin immunology, Clusterin therapeutic use, Cytokines drug effects, Cytokines immunology, Cytokines metabolism, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental drug therapy, Encephalomyelitis, Autoimmune, Experimental immunology, Encephalomyelitis, Autoimmune, Experimental physiopathology, Female, Hippocampus immunology, Hippocampus metabolism, Hippocampus pathology, Mice, Mice, Inbred C57BL, Myelin Basic Protein drug effects, Myelin Basic Protein immunology, Myelin Basic Protein metabolism, Myelin Sheath drug effects, Myelin Sheath immunology, Myelin Sheath pathology, Nerve Growth Factors immunology, Nerve Growth Factors therapeutic use, Nerve Regeneration immunology, Neurons drug effects, Neurons immunology, Neurons pathology, Organ Culture Techniques, Peripheral Nerves immunology, Peripheral Nerves physiopathology, Peripheral Nervous System Diseases immunology, Peripheral Nervous System Diseases physiopathology, Recombinant Proteins immunology, Recombinant Proteins pharmacology, Recombinant Proteins therapeutic use, Sciatic Neuropathy drug therapy, Sciatic Neuropathy immunology, Sciatic Neuropathy physiopathology, Treatment Outcome, Clusterin pharmacology, Nerve Growth Factors pharmacology, Nerve Regeneration drug effects, Peripheral Nerves drug effects, Peripheral Nervous System Diseases drug therapy
Abstract

Clusterin is a protein involved in multiple biological events, including neuronal cytoprotection, membrane recycling and regulation of complement-mediated membrane attack after injury. We investigated the effect of recombinant human clusterin in preclinical models of peripheral neuropathies. Daily treatment with clusterin accelerated the recovery of nerve motor evoked potential parameters after sciatic nerve injury. Prophylactic or therapeutic treatment of experimental autoimmune neuritis rats with clusterin also accelerated the rate of recovery from the disease, associated with remyelination of demyelinated nerve fibers. These data demonstrate that clusterin is capable of ameliorating clinical, neurophysiological and pathological signs in models of peripheral neuropathies.

Published
2007
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