1. A Transcriptome-Wide Association Study of Vestibular Schwannoma.
- Author
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Dambrino, Robert J., Lin, Phillip, Bledsoe, Xavier, Liles, Campbell, Thompson, Reid C., Morone, Peter J., and Gamazon, Eric R.
- Subjects
- *
ACOUSTIC neuroma , *NEUROFIBROMATOSIS 2 , *GENETIC models , *GENE expression - Abstract
This article, published in the Journal of Neurological Surgery, explores the genetic underpinnings of vestibular schwannoma (VS), a type of brain tumor. The study conducted a transcriptome-wide association study (TWAS) using genetic models of gene expression to identify gene-level associations with VS. The researchers identified 63 novel genes with genetically-determined expression associations with VS, including DNPH1, which has been previously associated with tinnitus. These findings provide new insights into the biological mechanisms associated with VS and may lead to the development of targeted therapies for this condition. [Extracted from the article]
- Published
- 2024
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