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Your search keyword '"Petzold, Axel"' showing total 15 results
Start Over Author "Petzold, Axel" Journal journal of neurology, neurosurgery & psychiatry
15 results on '"Petzold, Axel"'

1. Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders

Author

Oertel, Frederike Cosima, primary, Zimmermann, Hanna G, additional, Motamedi, Seyedamirhosein, additional, Chien, Claudia, additional, Aktas, Orhan, additional, Albrecht, Philipp, additional, Ringelstein, Marius, additional, Dcunha, Anitha, additional, Pandit, Lekha, additional, Martinez-Lapiscina, Elena H, additional, Sanchez-Dalmau, Bernardo, additional, Villoslada, Pablo, additional, Palace, Jacqueline, additional, Roca-Fernández, Adriana, additional, Leite, Maria Isabel, additional, Sharma, Srilakshmi M, additional, Leocani, Letizia, additional, Pisa, Marco, additional, Radaelli, Marta, additional, Lana-Peixoto, Marco Aurélio, additional, Fontenelle, Mariana Andrade, additional, Havla, Joachim, additional, Ashtari, Fereshteh, additional, Kafieh, Rahele, additional, Dehghani, Alireza, additional, Pourazizi, Mohsen, additional, Marignier, Romain, additional, Cobo-Calvo, Alvaro, additional, Asgari, Nasrin, additional, Jacob, Anu, additional, Huda, Saif, additional, Mao-Draayer, Yang, additional, Green, Ari J, additional, Kenney, Rachel, additional, Yeaman, Michael R, additional, Smith, Terry J, additional, Cook, Lawrence, additional, Brandt, Alexander U, additional, Paul, Friedemann, additional, and Petzold, Axel, additional

Published
2023
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4. Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders

Author

Lu, Angelo, primary, Zimmermann, Hanna G, additional, Specovius, Svenja, additional, Motamedi, Seyedamirhosein, additional, Chien, Claudia, additional, Bereuter, Charlotte, additional, Lana-Peixoto, Marco A, additional, Fontenelle, Mariana Andrade, additional, Ashtari, Fereshteh, additional, Kafieh, Rahele, additional, Dehghani, Alireza, additional, Pourazizi, Mohsen, additional, Pandit, Lekha, additional, D'Cunha, Anitha, additional, Kim, Ho Jin, additional, Hyun, Jae-Won, additional, Jung, Su-Kyung, additional, Leocani, Letizia, additional, Pisa, Marco, additional, Radaelli, Marta, additional, Siritho, Sasitorn, additional, May, Eugene F, additional, Tongco, Caryl, additional, De Sèze, Jérôme, additional, Senger, Thomas, additional, Palace, Jacqueline, additional, Roca-Fernández, Adriana, additional, Leite, Maria Isabel, additional, Sharma, Srilakshmi M, additional, Stiebel-Kalish, Hadas, additional, Asgari, Nasrin, additional, Soelberg, Kerstin Kathrine, additional, Martinez-Lapiscina, Elena H, additional, Havla, Joachim, additional, Mao-Draayer, Yang, additional, Rimler, Zoe, additional, Reid, Allyson, additional, Marignier, Romain, additional, Cobo-Calvo, Alvaro, additional, Altintas, Ayse, additional, Tanriverdi, Uygur, additional, Yildirim, Rengin, additional, Aktas, Orhan, additional, Ringelstein, Marius, additional, Albrecht, Philipp, additional, Tavares, Ivan Maynart, additional, Bichuetti, Denis Bernardi, additional, Jacob, Anu, additional, Huda, Saif, additional, Soto de Castillo, Ibis, additional, Petzold, Axel, additional, Green, Ari J, additional, Yeaman, Michael R, additional, Smith, Terry J, additional, Cook, Lawrence, additional, Paul, Friedemann, additional, Brandt, Alexander U, additional, and Oertel, Frederike Cosima, additional

Published
2021
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8. Retinal inter-eye difference and atrophy progression in multiple sclerosis diagnostics.

Author

Bijvank, Jenny Nij, Uitdehaag, B. M. J., Petzold, Axel, and Nij Bijvank, Jenny

Subjects
OPTIC neuritis, MULTIPLE sclerosis, ATROPHY, MULTIPLE sclerosis diagnosis, RETINA, NEURONS, OPTICAL coherence tomography, LONGITUDINAL method
Abstract

Background: The visual system could be included in the diagnostic criteria for multiple sclerosis (MS) to demonstrate dissemination in space (DIS) and dissemination in time (DIT).Objective: To investigate the diagnostic value of retinal asymmetry in MS.Methods: A prospective, longitudinal study in individuals with MS (n=151) and healthy controls (n=27). Optical coherence tomography (OCT) was performed at 0, 2 and 4 years. Macular ganglion cell and inner plexiform layer (mGCIPL) thickness was determined as well as measures for retinal asymmetry: the inter-eye percentage difference (IEPD) and inter-eye absolute difference (IEAD). Receiver operator characteristics curves were plotted and the area under the curve (AUC) was calculated for group comparisons of the mGCIPL, IEPD, IEAD and atrophy rates.Results: The diagnostic accuracy of both the IEPD and IEAD for differentiating bilateral and unilateral MS optic neuritis was high and stable over time (AUCs 0.88-0.93). The IEPD slightly outperformed the IEAD. Atrophy rates showed low discriminatory abilities for differentiating MS from controls (AUC 0.49-0.58).Conclusion: The inter-eye differences of the mGCIPL have value for demonstration of DIS but in individuals with longstanding MS not for DIT. This may be considered as a test to detect DIS in future diagnostic criteria. Validation in a large prospective study in people presenting with symptoms suggestive of MS is required. [ABSTRACT FROM AUTHOR]

Published
2022
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9. CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD

Author

Kleerekooper, Iris, primary, Herbert, Megan K, additional, Kuiperij, H Bea, additional, Sato, Douglas Kazutoshi, additional, Fujihara, Kazuo, additional, Callegaro, Dagoberto, additional, Marignier, Romain, additional, Saiz, Albert, additional, Senel, Makbule, additional, Tumani, Hayrettin, additional, De Jong, Brigit A, additional, Trip, S Anand, additional, Nakashima, Ichiro, additional, Verbeek, Marcel M, additional, and Petzold, Axel, additional

Published
2020
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14. Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study

Author

Lu, Ching-Hua, primary, Petzold, Axel, additional, Topping, Jo, additional, Allen, Kezia, additional, Macdonald-Wallis, Corrie, additional, Clarke, Jan, additional, Pearce, Neil, additional, Kuhle, Jens, additional, Giovannoni, Gavin, additional, Fratta, Pietro, additional, Sidle, Katie, additional, Fish, Mark, additional, Orrell, Richard, additional, Howard, Robin, additional, Greensmith, Linda, additional, and Malaspina, Andrea, additional

Published
2014
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15. Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.

Author

Ching-Hua Lu, Petzold, Axel, Topping, Jo, Allen, Kezia, Macdonald-Wallis, Corrie, Clarke, Jan, Pearce, Neil, Kuhle, Jens, Giovannoni, Gavin, Fratta, Pietro, Sidle, Katie, Fish, Mark, Orrell, Richard, Howard, Robin, Greensmith, Linda, and Malaspina, Andrea

Subjects
*AMYOTROPHIC lateral sclerosis, *CYTOPLASMIC filaments, *IMMUNOGLOBULIN heavy chains, *DISEASE progression, *BLOOD plasma, *SURVIVAL analysis (Biometry), *PHYSIOLOGY
Abstract

Objective: To investigate the role of longitudinal plasma neurofilament heavy chain protein (NfH) levels as an indicator of clinical progression and survival in amyotrophic lateral sclerosis (ALS). Methods: A cross-sectional study involving 136 clinically heterogeneous patients with ALS and 104 healthy and neurological controls was extended to include a prospective analysis of 74 of these ALS cases, with samplings at approximately 3-month intervals in a follow-up period of up to 3 years. We analysed the correlation between longitudinal NfH-phosphoform levels and disease progression. Temporal patterns of NfH changes were evaluated using multilevel linear regression. Results: Baseline plasma NfH levels were higher than controls only in patients with ALS with short disease duration to baseline sampling. Compared with controls, fast-progressing patients with ALS, particularly those with a short diagnostic latency and disease duration, had higher plasma NfH levels at an early stage and lower levels closer to end-stage disease. Lower NfH levels between visits were associated with rapid functional deterioration. We also detected antibodies against NfH, NfH aggregates and NfH cleavage products. Conclusions: Disease progression in ALS involves defined trajectories of plasma NfH levels, reflecting speed of neurological decline and survival. Intervisit plasma NfH changes are also indicative of disease progression. This study confirms that longitudinal measurements of NfH plasma levels are more informative than cross-sectional studies, where the time of sampling may represent a bias in the interpretation of the results. Autoantibodies against NfH aggregates and NfH cleavage products may explain the variable expression of plasma NfH with disease progression. [ABSTRACT FROM AUTHOR]

Published
2015
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