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Your search keyword '"Sato, Douglas Kazutoshi"' showing total 12 results
Start Over Author "Sato, Douglas Kazutoshi" Journal journal of neurology, neurosurgery & psychiatry
12 results on '"Sato, Douglas Kazutoshi"'

4. CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD

Author

Kleerekooper, Iris, primary, Herbert, Megan K, additional, Kuiperij, H Bea, additional, Sato, Douglas Kazutoshi, additional, Fujihara, Kazuo, additional, Callegaro, Dagoberto, additional, Marignier, Romain, additional, Saiz, Albert, additional, Senel, Makbule, additional, Tumani, Hayrettin, additional, De Jong, Brigit A, additional, Trip, S Anand, additional, Nakashima, Ichiro, additional, Verbeek, Marcel M, additional, and Petzold, Axel, additional

Published
2020
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5. CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications

Author

Kaneko, Kimihiko, primary, Sato, Douglas Kazutoshi, additional, Nakashima, Ichiro, additional, Ogawa, Ryo, additional, Akaishi, Tetsuya, additional, Takai, Yoshiki, additional, Nishiyama, Shuhei, additional, Takahashi, Toshiyuki, additional, Misu, Tatsuro, additional, Kuroda, Hiroshi, additional, Tanaka, Satoru, additional, Nomura, Kyoichi, additional, Hashimoto, Yuji, additional, Callegaro, Dagoberto, additional, Steinman, Lawrence, additional, Fujihara, Kazuo, additional, and Aoki, Masashi, additional

Published
2018
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6. Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies

Author

Fujimori, Juichi, primary, Takai, Yoshiki, additional, Nakashima, Ichiro, additional, Sato, Douglas Kazutoshi, additional, Takahashi, Toshiyuki, additional, Kaneko, Kimihiko, additional, Nishiyama, Shuhei, additional, Watanabe, Mika, additional, Tanji, Hiroaki, additional, Kobayashi, Michiko, additional, Misu, Tatsuro, additional, Aoki, Masashi, additional, and Fujihara, Kazuo, additional

Published
2017
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7. Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies

Author

Kaneko, Kimihiko, primary, Sato, Douglas Kazutoshi, additional, Nakashima, Ichiro, additional, Nishiyama, Shuhei, additional, Tanaka, Satoru, additional, Marignier, Romain, additional, Hyun, Jae-Won, additional, Oliveira, Luana Michelli de, additional, Reindl, Markus, additional, Seifert-Held, Thomas, additional, Sepulveda, Maria, additional, Siritho, Sasitorn, additional, Waters, Patrick Joseph, additional, Kurosawa, Kazuhiro, additional, Akaishi, Tetsuya, additional, Kuroda, Hiroshi, additional, Misu, Tatsuro, additional, Prayoonwiwat, Naraporn, additional, Berger, Thomas, additional, Saiz, Albert, additional, Kim, Ho Jin, additional, Nomura, Kyoichi, additional, Callegaro, Dagoberto, additional, Fujihara, Kazuo, additional, and Aoki, Masashi, additional

Published
2016
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8. CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications.

Author

Kimihiko Kaneko, Sato, Douglas Kazutoshi, Ichiro Nakashima, Ryo Ogawa, Tetsuya Akaishi, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Hiroshi Kuroda, Satoru Tanaka, Kyoichi Nomura, Yuji Hashimoto, Callegaro, Dagoberto, Steinman, Lawrence, Kazuo Fujihara, Masashi Aoki, Kaneko, Kimihiko, Nakashima, Ichiro, and Ogawa, Ryo

Subjects
CYTOKINES, CEREBROSPINAL fluid examination, MYELIN oligodendrocyte glycoprotein, NEUROMYELITIS optica, MULTIPLE sclerosis diagnosis, DIAGNOSIS of neurological disorders, CENTRAL nervous system diseases, DIAGNOSIS
Abstract

Objective: To evaluate cerebrospinal fluid (CSF) cytokine profiles in myelin oligodendrocyte glycoprotein IgG-positive (MOG-IgG+) disease in adult and paediatric patients.Methods: In this cross-sectional study, we measured 27 cytokines in the CSF of MOG-IgG+ disease in acute phase before treatment (n=29). The data were directly compared with those in aquaporin-4 antibody-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) (n=20), multiple sclerosis (MS) (n=20) and non-inflammatory controls (n=14).Results: In MOG-IgG+ disease, there was no female preponderance and the ages were younger (mean 18 years, range 3-68; 15 were below 18 years) relative to AQP4-IgG+ NMOSD (41, 15-77) and MS (34, 17-48). CSF cell counts were higher and oligoclonal IgG bands were mostly negative in MOG-IgG+ disease and AQP4-IgG+ NMOSD compared with MS. MOG-IgG+ disease had significantly elevated levels of interleukin (IL)-6, IL-8, granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor, interferon-γ, IL-10, IL-1 receptor antagonist, monocyte chemotactic protein-1 and macrophage inflammatory protein-1α as compared with MS. No cytokine in MOG-IgG+ disease was significantly different from AQP4-IgG+ NMOSD. Moreover many elevated cytokines were correlated with each other in MOG-IgG+ disease and AQP4-IgG+ NMOSD but not in MS. No difference in the data was seen between adult and paediatric MOG-IgG+ cases.Conclusions: The CSF cytokine profile in the acute phase of MOG-IgG+ disease is characterised by coordinated upregulation of T helper 17 (Th17) and other cytokines including some Th1-related and regulatory T cells-related ones in adults and children, which is similar to AQP4-IgG+ NMOSD but clearly different from MS. The results suggest that as with AQP4-IgG+ NMOSD, some disease-modifying drugs for MS may be ineffective in MOG-IgG+ disease while they may provide potential therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2018
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9. MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study: Table 1

Author

Akaishi, Tetsuya, primary, Sato, Douglas Kazutoshi, additional, Nakashima, Ichiro, additional, Takeshita, Takayuki, additional, Takahashi, Toshiyuki, additional, Doi, Hiroshi, additional, Kurosawa, Kazuhiro, additional, Kaneko, Kimihiko, additional, Kuroda, Hiroshi, additional, Nishiyama, Shuhei, additional, Misu, Tatsuro, additional, Nakazawa, Toru, additional, Fujihara, Kazuo, additional, and Aoki, Masashi, additional

Published
2015
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10. Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies.

Author

Juichi Fujimori, Yoshiki Takai, Ichiro Nakashima, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Kimihiko Kaneko, Shuhei Nishiyama, Mika Watanabe, Hiroaki Tanji, Michiko Kobayashi, Tatsuro Misu, Masashi Aoki, Kazuo Fujihara, Fujimori, Juichi, Takai, Yoshiki, Nakashima, Ichiro, Sato, Douglas Kazutoshi, Takahashi, Toshiyuki, Kaneko, Kimihiko, and Nishiyama, Shuhei

Subjects
FRONTAL lobe, CEREBRAL cortex, ENCEPHALITIS, PARAPARESIS, IMMUNOGLOBULINS
Published
2017
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11. Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies.

Author

Kimihiko Kaneko, Sato, Douglas Kazutoshi, Ichiro Nakashima, Shuhei Nishiyama, Satoru Tanaka, Marignier, Romain, Jae-Won Hyun, de Oliveira, Luana Michelli, Reindl, Markus, Seifert-Held, Thomas, Sepulveda, Maria, Siritho, Sasitorn, Waters, Patrick Joseph, Kazuhiro Kurosawa, Tetsuya Akaishi, Hiroshi Kuroda, Tatsuro Misu, Prayoonwiwat, Naraporn, Berger, Thomas, and Saiz, Albert

Subjects
NEUROLOGICAL disorders, THERAPEUTICS, CELLULAR pathology, AQUAPORINS, MYELIN sheath diseases, OLIGODENDROGLIA, AUTOANTIBODIES, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, MEMBRANE proteins, MULTIPLE sclerosis, NERVE tissue, NEURODEGENERATION, RESEARCH, EVALUATION research, MEMBRANE glycoproteins
Published
2016
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12. MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study.

Author

Tetsuya Akaishi, Sato, Douglas Kazutoshi, Ichiro Nakashima, Takayuki Takeshita, Toshiyuki Takahashi, Hiroshi Doi, Kazuhiro Kurosawa, Kimihiko Kaneko, Hiroshi Kuroda, Shuhei Nishiyama, Tatsuro Misu, Toru Nakazawa, Kazuo Fujihara, Masashi Aoki, Akaishi, Tetsuya, Nakashima, Ichiro, Takeshita, Takayuki, Takahashi, Toshiyuki, Doi, Hiroshi, and Kurosawa, Kazuhiro

Subjects
*OPTIC neuritis, *MAGNETIC resonance imaging, *MEDICAL imaging systems, *RETINA abnormalities, *OPTICAL coherence tomography, *OLIGODENDROGLIA, *GLYCOPROTEIN hormones, *DIAGNOSIS, *COMPARATIVE studies, *CONVALESCENCE, *EYE, *EYE-sockets, *RESEARCH methodology, *MEDICAL cooperation, *MEMBRANE proteins, *RESEARCH, *RETINA, *EVALUATION research, *MEMBRANE glycoproteins
Abstract

The article presents the study on the magnetic resonance imaging (MRI) retinal abnormalities characterization of isolated optic neuritis (ON) among seropositive antiaquaporin- 4 (anti-AQP4) and antimyelin oligodendrocyte glycoprotein (anti-MOG) patients. Topics include the spectral domain optical coherence tomography (OCT) method, the comparison of MRI findings, and the results on the clinical recovery and anti-MOG serological status of the patients after the treatment.

Published
2016
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