1. Vestibular impairment in Charcot–Marie–Tooth disease
- Author
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Elçin Bora, Koray Koçoğlu, Gülden Akdal, H. Karasoy, İhsan Şükrü Şengün, Ayşe Nur Yüceyar, Özgül Ekmekci, Tural Tanriverdizade, Fikret Bademkiran, and Ege Üniversitesi
- Subjects
Balance ,medicine.medical_specialty ,genetic structures ,Sensory system ,Audiology ,Somatosensory system ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,Postural Balance ,Video head impulse test ,Medicine ,030212 general & internal medicine ,Balance (ability) ,Vestibular system ,Vestibulo-ocular reflex ,business.industry ,Head impulse test ,Reliability ,Neurology ,Reflex ,Modified clinical test of sensory integration in balance ,sense organs ,Neurology (clinical) ,Vestibulo–ocular reflex ,business ,030217 neurology & neurosurgery ,CMT disease - Abstract
Objective: To find out if Charcot–Marie–Tooth (CMT) patients, who have peripheral vestibular as well as peripheral somatosensory impairment, have worse postural balance than those who do not. Methods: We studied 32 patients with various CMT phenotypes and genotypes. Vestibular function was measured with the video head impulse test (vHIT) which tests vestibulo-ocular reflex (VOR) gain from each of the six semicircular canals in response to rapid head rotations. Postural balance was evaluated with a battery of four postural tests with emphasis on the modified clinical test of sensory integration in balance (mCTSIB). Results: Half of the 32 patients had some impairment of vestibular function ranging from mild, affecting only 1–2 semicircular canals, to almost total affecting all 6 semicircular canals. Their mCTSIB scores correlated with VOR gain from the vertical rather than from the lateral semicircular canals. The worse the vertical VOR gain the worse the mCTSIB score. Conclusion: We propose that any CMT patient could have clinically inapparent vestibular impairment that can be easily measured with the vHIT. This vestibular impairment could be contributing to their imbalance and could respond to a focused vestibular rehabilitation program. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature., 216S658 Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK, Study funded by the Scientific and Technological Research Council of Turkey (TÜBİTAK) under Grant no. (216S658). Acknowledgements
- Published
- 2020