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When given a choice between actions that yield the same reward, we tend to prefer the one that requires the least effort. Recent studies have shown that humans are remarkably accurate at evaluating the effort of potential reaching actions and can predict the subtle energetic demand caused by the nonisotropic biomechanical properties of the arm. In the present study, we investigated the time course over which such information is computed and comes to influence decisions. Two independent approaches were used. First, subjects performed a reach decision task in which the time interval for deciding between two candidate reaching actions was varied from 200 to 800 ms. Second, we measured motor-evoked potential (MEPs) to single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) to probe the evolving decision at different times after stimulus presentation. Both studies yielded a consistent conclusion: that a prediction of the effort associated with candidate movements is computed very quickly and influences decisions within 200 ms after presentation of the candidate actions. Furthermore, whereas the MEPs measured 150 ms after stimulus presentation were well correlated with the choices that subjects ultimately made, later in the trial the MEP amplitudes were primarily related to the muscular requirements of the chosen movement. This suggests that corticospinal excitability (CSE) initially reflects a competition between candidate actions and later changes to reflect the processes of preparing to implement the winning action choice [ABSTRACT FROM AUTHOR]

There is considerable debate on the extent to which biomechanical properties of movements are taken into account before and during voluntary movements. For example, while several models have described reach planning as primarily kinematic, some studies have suggested that implicit knowledge about biomechanics may also exert some influence on the planning of reaching movements. Here, we investigated whether decisions about reaching movements are influenced by biomechanical factors and whether these factors are taken into account before movement onset. To this end, we designed an experimental paradigm in which humans made free choices between two potential reaching movements where the options varied in path distance as well as biomechanical factors related to movement energy and stability. Our results suggest that the biomechanical properties of potential actions strongly influence the selection between them. In particular, in our task, subjects preferred movements whose final trajectory was better aligned with the major axis of the arm's mobility ellipse, even when the launching properties were very similar. This reveals that the nervous system can predict biomechanical properties of potential actions before movement onset and that these predictions, in addition to purely abstract criteria, may influence the decisionmaking process. [ABSTRACT FROM AUTHOR]