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Your search keyword '"Reddy, U."' showing total 4 results
Start Over Author "Reddy, U." Journal journal of neuroscience research
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4. Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5).

Author

Scarlato M, Xu T, Bannerman P, Beesley J, Reddy UR, Rostami A, Scherer SS, and Pleasure D

Subjects
Animals, Axotomy, Cell Communication physiology, Cells, Cultured, Colforsin pharmacology, Cyclic AMP metabolism, Fibroblast Growth Factor 5, Gene Expression drug effects, Gene Expression physiology, RNA, Messenger analysis, Rats, Rats, Inbred Lew, Schwann Cells cytology, Sciatic Nerve cytology, Wallerian Degeneration physiopathology, Axons physiology, Fibroblast Growth Factors genetics, Nerve Regeneration physiology, Schwann Cells physiology, Sciatic Nerve physiology
Abstract

We screened for genes whose expression is significantly up- or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor-5 (FGF-5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF-5 in axotomized nerve. Axon-Schwann cell interactions decreased the steady-state level of FGF-5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF-5, which is a secreted, neuronotrophic member of the FGF family., (Copyright 2001 Wiley-Liss, Inc.)

Published
2001
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