1. Raloxifene inhibits cholesterol aortic content but not atherosclerotic plaque size in oophorectomised cholesterol-fed rabbits
- Author
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A. Sanjuán, Marta Colodrón, Camil Castelo-Branco, Elena Casals, J J Vicente, Jaume Ordi, Geòrgia Escaramís, Juan E. Blümel, Carlos Ascaso, Immaculada Mercader, and J. A. Vanrell
- Subjects
Selective Estrogen Receptor Modulators ,medicine.medical_specialty ,Arteriosclerosis ,Ovariectomy ,Osteoporosis ,Selective oestrogen receptor modulator ,Placebo ,Endometrium ,Sensitivity and Specificity ,Cholesterol, Dietary ,chemistry.chemical_compound ,Random Allocation ,Reference Values ,medicine.artery ,Internal medicine ,Biopsy ,medicine ,Animals ,Raloxifene ,Aorta ,Probability ,Analysis of Variance ,medicine.diagnostic_test ,business.industry ,Cholesterol ,Biopsy, Needle ,Cholesterol, HDL ,Obstetrics and Gynecology ,Cholesterol, LDL ,medicine.disease ,Immunohistochemistry ,Lipoproteins, LDL ,Disease Models, Animal ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Area Under Curve ,Raloxifene Hydrochloride ,Female ,Rabbits ,business ,medicine.drug - Abstract
Raloxifene, a selective oestrogen receptor modulator, is effective in the treatment of osteoporosis without stimulating the breast and the endometrium. Although it is associated with a decrease of cardiovascular risk markers the effect of these changes on atherogenesis, is not clear. In this study, we aimed to investigate the effect of raloxifene on aorta atherogenesis. A total of 32 cholesterol-fed New Zealand white rabbits were studied for 4 months. Twenty-four rabbits underwent bilateral ovariectomy; of these eight received raloxifene (group OR), eight received oestradiol valerate (group OE) and eight received placebo after sterilisation (group OP). Finally, another eight were sham-operated (non-ovariectomised) and received placebo with a hypercholesterolaemic diet (group SP). After the diet, total levels of cholesterol increased in group SP from 111.25 +/- 34.8 mg/dl to 1112.25 +/- 364.2, in group OP from 122.62 +/- 27.7 mg/dl to 1367.37 +/- 348.4, in group OE from 65.25 +/- 17.01 to 1710.5 +/- 356.2 and in group OR from 108.88 +/- 15.54 mg/dl to 1407.86 +/- 397.7 (no significant differences). At 4 months, in both treated and untreated rabbits, the cholesterol-rich diet caused atherosclerotic lesions affecting 24.51 +/- 16.1% for group SP, 30.47 +/- 12.2% for group OP, 30.31 +/- 18.07% for group OR and 17.91 +/- 10.19 for group OE (P
- Published
- 2003