1. Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders--The COVID-19 Arapahoe SErosurveillance Study (CASES) Project.
- Author
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Sabourin, Katherine R., Schultz, Jonathan, Romero, Joshua, Lamb, Molly M., Larremore, Daniel, Morrison, Thomas E., Frazer-Abel, Ashley, Zimmer, Shanta, Kedl, Ross M., Jaenisch, Thomas, and Rochford, Rosemary
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COVID-19 , *IMMUNOGLOBULINS , *LUNG diseases , *ENZYME-linked immunosorbent assay , *DESCRIPTIVE statistics , *POLICE - Abstract
Objectives: Define the seroprevalence and risk factors for SARS-CoV-2 antibodies in Arapahoe County, Colorado first responders (eg, law enforcement, human services, fire departments). Methods: Two hundred sixty four first responders were enrolled June to July 2020. SARS-CoV-2 seropositivity was defined as detection of immunoglobulin G (IgG) antibodies to both spike receptor binding domain and nucleocapsid in venous blood by validated enzyme-linked immunosorbent assay. We compared risk factors for being seropositive versus seronegative. Results: 4% (11/264) were SARS-CoV-2 seropositive. Seropositive participants were significantly more likely to have lung disease (% seropositive, % seronegative; P-value) (36%, 8%: P = 0.01), prior SARS-CoV-2/COVID-19 testing (36%, 8%; P ≤ 0.01), a prior positive result (18%, less than 1%), and to believe they previously had COVID-19 (64%, 15%; P < 0.01). Only 15% of those believing they had COVID-19 had anti-SARS-CoV-2 antibodies. Conclusions: Human services employees and individuals with lung disease are at SARS-CoV-2 exposure risk. Few individuals believed they had COVID-19 had prior exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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