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Carbon disulfide (CS[sub 2]) is a man-made product utilized primarily in the manufacture of viscose rayon. Overexposure to CS[sub 2] has been associated with an increase in coronary heart disease. The aims of this study were to examine the dose-response relationship of CS[sub 2] exposure and elevated lipid profile tests among CS[sub 2]-exposed workers in Taiwan. A total of 132 workers were recruited from two viscose rayon plants. Air sampling was performed to determine the CS[sub 2] exposure of workers. Demographic data and work history were gathered by a standard self-administered questionnaire. Lipid profile tests were also performed by routine methods. The average CS[sub 2] exposure concentration was 50.6 ± 25.6 ppm (range: 24-127 ppm) in the high-exposure group, 12.9 ± 5 ppm (range: 5.2-22.3 ppm) in the mid-exposure group, and 3.5 ± 1.2 ppm (range 0.97-5.2 ppm) in the low-exposure group. There were 21 out of 33 (63.7%) elevated triglyceride levels among high-CS[sub 2]-exposure workers, 27 out of 64 (42.2%) among the middle-CS[sub 2]-exposure, and 14 out of 35 (40%) among low-CS[sub 2]exposure workers, respectively. Compared to the low-CS[sub 2]-exposure workers, the age- and weightadjusted odds ratios (and 95% confidence intervals) of the prevalence of elevated triglyceride value were 1.12 (0.5, 2.7) for middle-CS[sub 2]-exposure workers, and 2.81 (1.02, 7.8) for high-CS[sub 2]-exposure workers. There was a significant linear trend between CS[sub 2] exposure and the prevalence of elevated triglyceride value (P = 0.046) after adjusting for other factors. There was also a lower prevalence of elevated HDL levd in high-CS[sub 2]-exposure workers than low-CS[sub 2]-exposure workers (15.2% versus 31.4%). Compared to the low-CS[sub 2]-exposure workers, the age- and weight-adjusted odds ratio (and 95% confidence intervals) of elevated HDL level were 0.34 (0.1, 1.18) for high-CS[sub 2]-exposure workers, which was borderline significant. In... [ABSTRACT FROM AUTHOR]

Presents information on a study which used enzyme-linked immunosorbent assays to detect mutant p53 protein and anti-p53 antibodies in the plasma of vinyl chloride. Methodology; Results; Limitations of the study.

Discusses a study that evaluated Asp 13-p21-Ki-ras in the sera of vinyl chloride (VC)-exposed workers in Taiwan using enhanced chemiluminescense Western blotting. How the study was conducted; Results of the study; Discussion of results.

Assesses the risk of pulmonary diseases of persons working at a semiconductor plant in Taiwan. Methods used to conduct studies on employees at the plant; Details on the prevalence of lung function abnormalities among males; Indication that the electronics industry is one of the largest industries in the world; Average number of persons employed in the electronics industry.