1. Neutrophil–lymphocyte ratio as a prognostic factor for survival in patients with advanced renal cell carcinoma (Turkish Oncology Group Study)
- Author
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Kadriye Bir Yucel, Umut Demirci, Hatime Arzu Yasar, Yuksel Urun, Burak Bilgin, Mehmet An Şendur, Hakan Taban, Bulent Yalcin, Nuri Karadurmus, Cagatay Arslan, Gokhan Ucar, Serdar Karakaya, Nuriye Yildirim, Ismail Erturk, Irfan Cicin, Ahmet Kucukarda, Saadettin Kilickap, and Mutlu Hizal
- Subjects
Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Neutrophils ,Turkish ,Lymphocyte ,Cell ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Interferon ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,In patient ,Lymphocytes ,Carcinoma, Renal Cell ,Retrospective Studies ,Group study ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Kidney Neoplasms ,language.human_language ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,language ,Female ,business ,Value (mathematics) ,medicine.drug - Abstract
Background To describe the prognostic value of neutrophil–lymphocyte ratio and its effect on survival in in patients with advanced renal cell carcinoma. Methods We retrospectively analyzed 331 patients. The cut-off value of neutrophil–lymphocyte ratio was specified as “3” which is mostly close—and also clinically easily applicable—to the median neutrophil–lymphocyte ratio level of our study group. High group is identified as neutrophil–lymphocyte ratio >3 (n = 160) and low group is identified as neutrophil–lymphocyte ratio ≤3 (n = 163). Results A total of 331 (with 211 male and 120 female) patients were enrolled to study. The median age of the patients was 58. The International Metastatic RCC Database Consortium risk score is calculated for the 72.8% (n = 241) of the study group and among these patients, favorable, intermediate, and poor risk rates were 22, 45.2, and 32.8%. The total usage of tyrosine kinase inhibitors reached 78% of the patients. The median overall survival was 32 months versus 11 months in the neutrophil–lymphocyte ratio low and high groups, respectively (HR: 0.49 (95% CI 0.37–0.65), p Conclusion In conclusion, the pre-treatment value of elevated neutrophil–lymphocyte ratio might be a predictor of poor overall survival in advanced renal cell carcinoma patients.
- Published
- 2020
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