3 results on '"Phillips, Ceib L."'
Search Results
2. The presence of neuropathic pain predicts postoperative neuropathic pain following trigeminal nerve repair.
- Author
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Zuniga JR, Yates DM, and Phillips CL
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Pain, Postoperative complications, Young Adult, Neuralgia complications, Oral Surgical Procedures adverse effects, Pain, Postoperative etiology, Trigeminal Nerve surgery
- Abstract
Purpose: The risk for the continuation or recurrence of neuropathic pain following trigeminal nerve repair has never been examined. The objective of this study was to determine which risk factors might be associated with the continuation or recurrence of neuropathic pain following trigeminal nerve microneurosurgery., Patients and Methods: An ambispective study design was used to assess subjects who underwent trigeminal nerve repair of the inferior alveolar nerve and lingual nerve between 2000 and 2010. The primary outcome was the presence or absence of neuropathic pain at 3, 6, and 12 months after surgery. Explanatory variables, including age at surgery, gender, presence of neuropathic pain before surgery, site of nerve injury, etiology of nerve injury, classification of nerve injury, duration of nerve injury, and type of repair performed, were abstracted from patient charts. Fisher exact tests were used to compare the demographic and injury characteristics of patients who presented with pain before surgery and those who did not. The McNemar test was used to assess whether there was a significant change in neuropathic pain report from before to after surgery. The level of significance was set at .50., Results: Of the 65 patients analyzed, two-thirds were women; the average age was 36±16.1 years, and the median time between the injury and surgery was 6.4 months (interquartile range, 6.7 months). Lingual nerve injury type was the most frequent (62%). There was no statistically significant change in pain status from before to after surgery (P=.104). Only 1 patient had pain after surgery who had not had pain before surgery, while 67% of those with pain before surgery continued to have pain after surgery. Pain prior to surgery as a predictor of pain after had sensitivity of 91%, specificity of 88%, positive predictive value of 67%, and negative predictive value 97%., Conclusions: The presence of neuropathic pain prior to trigeminal microneurosurgery is the major risk factor for the continuation or recurrence of postoperative neuropathic pain. These findings suggest that trigeminal nerve surgery is not a risk factor for developing neuropathic pain in the absence of neuropathic pain before surgery., (Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
3. Analgesic safety and efficacy of diclofenac sodium softgels on postoperative third molar extraction pain.
- Author
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Zuniga JR, Phillips CL, Shugars D, Lyon JA, Peroutka SJ, Swarbrick J, and Bon C
- Subjects
- Adolescent, Adult, Analgesics, Non-Narcotic blood, Analysis of Variance, Anti-Inflammatory Agents, Non-Steroidal blood, Capsules, Diclofenac blood, Female, Humans, Male, Pain Measurement, Patient Satisfaction, Placebos, Single-Blind Method, Time Factors, Treatment Outcome, Analgesics, Non-Narcotic therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Diclofenac therapeutic use, Molar, Third surgery, Pain, Postoperative drug therapy, Tooth Extraction adverse effects, Tooth, Impacted surgery
- Abstract
Purpose: The purpose of this single-blind, placebo-controlled, 3-arm parallel, randomized study was to compare the analgesic efficacy and tolerability of a single dose of 100 mg diclofenac potassium (Cataflam; Novartis, Stein, Switzerland), 100 mg diclofenac sodium softgel, and placebo in patients experiencing moderate to severe postoperative pain after third molar extraction., Patients and Methods: Seventy-five patients (67% female with a mean age of 23, age range 18 to 34.5 years) participated in the study following removal of at least 1 impacted mandibular third molar. Patients received a single dose of study medication when their postoperative pain reached a moderate or severe intensity. Analgesic efficacy measures included the time to meaningful pain relief measured using a stopwatch and time to rescue medication. Pain relief (PR) and Pain intensity (PI) ratings were recorded at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 8, and 24 hours postdosing. Summary analgesic measures, including Summed Pain Relief Score (TOTPAR) and Summed Pain Intensity Differences (SPID), were calculated from the 0.25- to 6-hour responses. The time between pain relief and rescue and a global evaluation for the effectiveness of the study medications were recorded at the end of the study. Seven scheduled blood samples were collected from each patient for determining plasma concentrations of diclofenac anion., Results: Both diclofenac sodium softgel and Cataflam were significantly more effective than placebo (P <.0001) for all summary analgesic measures. The average overall pain relief was substantially better from diclofenac sodium softgel than from Cataflam, but the difference was not statistically significant (P =.14). In patients taking diclofenac sodium softgel, 50% of the patients experienced a time to onset of analgesic activity within 18 minutes and the median analgesic duration was 5 hours (302 minutes). Fifty percent of the patients taking Cataflam had a time to onset of action within 38 minutes, and the median duration of analgesia was 4.5 hours (272 minutes). At the time of rescue drug administration or 6 hours, whichever was earlier, 72% of the patients given diclofenac sodium softgel rated the medication as a very good or excellent pain reliever, whereas only 45% of the patients taking Cataflam gave these ratings. No serious adverse events were observed in this study. The mean concentrations of diclofenac from the diclofenac sodium softgel formulation were significantly different from the Cataflam formulation. The mean C(max) for the softgel was almost twice that of Cataflam and C(max) was reached an hour earlier, on average., Conclusions: More diclofenac anion was absorbed at a quicker rate using the formulation diclofenac sodium softgel 100 mg than Cataflam. The softgel provided a very rapid onset of analgesic activity, a prolonged analgesic duration, and an acceptable side-effect profile in the postoperative third molar surgery pain model. In an acute pain situation, the rapid absorption of nonsteroidal anti-inflammatory drugs from a formulation like the Softgel may positively affect the time of onset and duration of inflammatory pain compared with other commercially available nonsteroidal anti-inflammatory drug formulations.
- Published
- 2004
- Full Text
- View/download PDF
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