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Start Over Descriptor "Contrast media -- Optical properties" Journal journal of organic chemistry
1 results on '"Contrast media -- Optical properties"'

1. Synthesis of heteroatom substituted naphthoporphyrazine derivatives with near-infrared absorption and emission

Author

Trivedi, Evan R., Sangwan Lee, Hong Zong, Blumenfeld, Carl M., Barrett, Anthony G.M., and Hoffman, Brian M.

Subjects
Carcinoma -- Research, Cancer -- Research, Contrast media -- Chemical properties, Contrast media -- Optical properties, Naphthalene -- Chemical properties, Naphthalene -- Structure, Porphyrins -- Chemical properties, Substitution reactions -- Analysis, Biological sciences, Chemistry
Abstract

An effective new optical contrast agents is developed by describing the synthesis of porphyrazines (pzs) of the form [H.sub.2][pz([A.sub.4-n];[C.sub.n])] (A = peripheral heteroatom (S- and O-) R-groups and C is a fused, [bta],[bta]'-diisopropyloxynaphtho group). Emission from the oxygen-atom appended naphtho-pzs is observed within carcinoma cells, which has confirmed the cellular uptake and their potential use as optical agents.

Published
2010

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