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Your search keyword '"Kärkäs, Markus D."' showing total 5 results
Start Over Author "Kärkäs, Markus D." Journal journal of organic chemistry
5 results on '"Kärkäs, Markus D."'

5. Silver-Assisted [3 + 2] Annulation of Nitrones with Isocyanides: Synthesis of 2,3,4-Trisubstituted 1,2,4-Oxadiazolidin-5-ones.

Author

Shen X, Shatskiy A, Chen Y, Kärkäs MD, Wang XS, and Liu JQ

Abstract

A silver-assisted method for [3 + 2] annulation of nitrones with isocyanides has been developed. The developed protocol allows access to a variety of 2,3,4-trisubstituted 1,2,4-oxadiazolidin-5-one derivatives as single diastereomers in good to excellent yields using silver oxide as the catalyst and molecular oxygen as the terminal oxidant. A plausible mechanism involving a nucleophilic addition/cyclization/protodeargentation/oxidation pathway is proposed on the basis of experimental results.

Published
2020
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