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Your search keyword '"Koguma, Tetsuhiko"' showing total 1 results
Start Over Author "Koguma, Tetsuhiko" Journal journal of organic chemistry
1 results on '"Koguma, Tetsuhiko"'

1. Theoretical and experimental considerations on the hammerhead ribozyme reactions: divalent magnesium ion mediated cleavage of phosphorus-oxygen bonds

Author

Uebayasi, Masami, Uchimaru, Tadafumi, Koguma, Tetsuhiko, Sawata, Shinya, Shimayama, Takashi, and Taira, Kazunari

Subjects
Organophosphorus compounds -- Research, Scission (Chemistry) -- Analysis, Catalytic RNA -- Research, Magnesium -- Research, Metal ions -- Research, Biological sciences, Chemistry
Abstract

Theoretical studies using ab initio calculations and kinetic experiments demonstrate the ability of magnesium ion to cleave a phosphorus-oxygen bond by directly coordinating with the translating oxygen. This direct coordination favors the second step of the hammerhead ribozyme reactions. A comparative study of the stabilities of oxyphosphoranes with different ionic valences reveals that stability is increased by the protonation of a dianionic species.

Published
1994

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