Search

Your search keyword '"Lingmin Wu"' showing total 2 results
Start Over Author "Lingmin Wu" Journal journal of organic chemistry
2 results on '"Lingmin Wu"'

1. Synthesis of Trifluoromethyl-Containing Vicinal Diamines by Asymmetric Decarboxylative Mannich Addition Reactions.

Author

Lingmin Wu, Chen Xie, Haibo Mei, Yanling Dai, Jianlin Han, Soloshonok, Vadim A., and Yi Pan

Subjects
*MANNICH reaction, *ADDITION reactions, *DIAMINES, *CHEMICAL synthesis, *TRIFLUOROMETHYL compounds
Abstract

Herein is reported a study of asymmetric decarboxylative Mannich addition reactions between (Ss)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine and Schiff bases derived from various aldehydes and lithium 2,2-diphenylglycinate. These reactions proceed with excellent diastereoselectivities and good chemical yields, providing a practical method for preparation of trifluoromethyl-containing vicinal diamines. The procedures can be conducted under convenient conditions, rendering this approach of high synthetic value. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

2. Asymmetric Friedel--Crafts Reactions of N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimines: General Access to Enantiomerically Pure Indoles Containing a 1-Amino-2,2,2-trifluoroethyl Group.

Author

Lingmin Wu, Chen Xie, Haibo Mei, Soloshonok, Vadim A., Jianlin Han, and Yi Pan

Subjects
*FRIEDEL-Crafts reaction, *INDOLE, *CHEMICAL research, *AMINO compounds, *CHEMICAL synthesis
Abstract

We have demonstrated that 3,3,3-trifluoroacetaldimine (S)-1 easily reacts with indole derivatives under Friedel-Crafts reactions to provide reliable and generalized access to biologically interesting compounds containing the CF3CH(NH2)-pharmacophoric group. The reactions proceed with high rates and generally excellent yields (>90%) and stereochemical outcomes (99:1 dr). [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results