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Start Over Author "Paweł Lenartowicz" Journal journal of organic chemistry
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1. Access to α-Aminophosphonic Acid Derivatives and Phosphonopeptides by [Rh(P–OP)]-Catalyzed Stereoselective Hydrogenation

Author

Arnald Grabulosa, Héctor Fernández-Pérez, Lucas Carreras, Paweł Kafarski, Paweł Lenartowicz, and Anton Vidal-Ferran

Subjects
010405 organic chemistry, Chemistry, Ligand, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, Catalysis, Rhodium, Derivative (finance), Molecule, Stereoselectivity
Abstract

The hydrogenation of N-substituted vinylphosphonates using rhodium complexes derived from P–OP ligands L1, ent-L1, or (R,R)-Me-DuPHOS as catalysts has been successfully accomplished, achieving very high levels of stereoselectivity (up to 99% ee or de). The described synthetic strategy allowed for the efficient preparation of α-aminophosphonic acid derivatives and phosphonopeptides, which are valuable building blocks for the preparation of biologically relevant molecules.

Published
2020

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