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Start Over Descriptor "Vitamin D3 -- Chemical properties" Journal journal of organic chemistry
1 results on '"Vitamin D3 -- Chemical properties"'

1. Synthesis of vitamin D3 and calcitriol dimers as potential chemical inducers of vitamin D receptor dimerization

Author

Sestelo, Jose Perez, Mourino, Antonio, Sarandeses, Luis A., Jarry, Christian, and Robba, Max

Subjects
Metabolism -- Research, Protein binding -- Research, Protein binding -- Chemical properties, Vitamin D3 -- Research, Vitamin D3 -- Chemical properties, Vitamin D3 -- Atomic properties, Biological sciences, Chemistry
Abstract

The design and synthesis of vitamin D3 dimers and 1alpha,25-dihydroxyvitamin D3(calcitriol) dimers are described with a view to doubly bind the vitamin D receptor (VDR) and inducting homodimerization. By using Wittig-Horner approach to construct the vitamin D triene system and prepare the dimers with a linker of modulated length with the purpose of optimizing the vitamin D3-VDR interaction is also discussed. more...

Published
2000

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