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The alternative method of cyclopropane compounds preparation has been discussed. The method involves sulfur-ylide-induced cyclopropanation of enolates that bear the difluoromethylenephosphonate group.

A cationic rhodium(I) complex- or In(OTf)3-catalyzed synthesis of phenol derivatives from cyclohex-2-enone having an ethoxycarbonyl-substituted alkyne has been achieved. This reaction proceeds via enolization and an intramolecular Alder--Rickert reaction. [ABSTRACT FROM AUTHOR]

A diastereoselective synthesis of the Leu-Pro type phosphinyl dipeptide isostere in its protected form was achieved from stereodefined α-amino-H-phosphinate. The methodology involved a cross-coupling reaction with alkenyl triflate and subsequent diastereoselective hydrogenation of the alkene moiety, which capitalized on the phosphorus chirality. [ABSTRACT FROM AUTHOR]

A highly diastereoselective synthesis of 2-amino alcohol derivatives bearing a difluoromethylphosphonothioate group at the 3-position was achieved through LiAIH(O-t-Bu) 5-mediated reduction of the corresponding a-amino ketones. The phosphonothioate moiety of the product was readily converted into the corresponding phosphonate by oxidation with m-CPBA, followed by aqueous workup. The developed meLhods should be useful for SAR studies of SMA-7, a potent inhibitor of SMates. [ABSTRACT FROM AUTHOR]