1. Air-stable and highly efficient indenyl-derived phosphine ligand: Application to Buchwald–Hartwig amination reactions
- Author
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Jia Yuan, Xiaowei Hao, Ming-Qiang Qiu, Shu-Lan Mao, Yue Sun, Neng-Fang She, Jun Yin, Guang-Ao Yu, Cui Zhao, and Sheng Hua Liu
- Subjects
Ligand ,Chemistry ,Aryl ,Organic Chemistry ,Halide ,chemistry.chemical_element ,Buchwald–Hartwig amination ,Biochemistry ,Combinatorial chemistry ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,Materials Chemistry ,Organic chemistry ,Physical and Theoretical Chemistry ,Amination ,Phosphine ,Palladium - Abstract
2-Mesitylindenyl phosphine ligand (1) and [(2-mesitylindenyl)dicyclohexyl-phosphine]PdCl2 (2) have been synthesized and fully characterized by NMR and elemental analysis, as well as by X-ray crystallography for 2. A Highly active catalyst system derived from a palladium precatalyst and bulky 2-mesitylindenyl phosphine ligand (1) for the Buchwald–Hartwig amination reaction of aryl halides with primary and secondary amines has been developed. This method allows for the preparation of a wide variety of amines in moderate to excellent yields and displays a high level of activity for the coupling of aryl chlorides as well as hindered aryl bromides.
- Published
- 2012
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