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Objective: To assess the rate of anxiety and depression in the patients suffering from various medical diseases. Design: Cross sectional study. Palace and Duration of Study: The study was conducted in District Headquarter Hospital and Allied Hospital, Faisalabad from 2005 to 2007. Subjects and Methods: Participants were inducted in the study through purposive convenient sampling technique. 339 patients of cardiac, cancer, hepatic, and dermatological diseases from both the above mentioned hospitals participated in this study. Co morbidity of psychiatric disorders was screened out with the help of DSM IV TR's criteria for depression and generalized anxiety. Results: Anxiety (n=32, 9.43%) was the major diagnosis in age group 40 - 49 and depression (n=31, 9.14%) in age group 50 - 59. All the diagnosis i.e., anxiety (n=30, 8.84%), depression (n=51, 15.04%) and both anxiety and depression (n=25, 7.37%) were common in illiterate patients. Anxiety (n=37, 10.91%) and depression (n=57, 16.81%) was found more in housewives. All the diagnosis i.e., anxiety (n=77, 22.71%), depression (n=93, 27.43%) and both anxiety and depression (n=45, 13.27%) were common in married patients. Anxiety (n=54, 15.92%) was common in hepatic patients and cardiac patients were having highest share of depression (n=51, 15.04%) and both anxiety and depression (n=32, 9.43%). Conclusion: Most cardiac patients were depressed; most heaptic patinets were anxious; almost half of cancer patients were both anxious and depressed; while majority of dermatological patients were having no psychiatric illness. [ABSTRACT FROM AUTHOR]