1. An Atypical Case of Thrombotic Microangiopathy Secondary to Acute Pancreatitis
- Author
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Arnaud Wautlet, Shivi Jain, and Andrew Vissing
- Subjects
Hemolytic anemia ,Male ,medicine.medical_specialty ,Thrombotic microangiopathy ,Adolescent ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,Internal medicine ,Atypical hemolytic uremic syndrome ,medicine ,Humans ,Blood Transfusion ,Atypical Hemolytic Uremic Syndrome ,business.industry ,Thrombotic Microangiopathies ,Hematology ,Microangiopathic hemolytic anemia ,Eculizumab ,medicine.disease ,Oncology ,Pancreatitis ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Etiology ,Acute pancreatitis ,business ,030215 immunology ,medicine.drug - Abstract
Thrombotic microangiopathies (TMAs) are a group of disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage. It can often be challenging to determine the underlying etiology. Our patient presented with acute pancreatitis and later developed thrombocytopenia and hemolytic anemia, along with acute renal failure. A working diagnosis of an atypical hemolytic uremic syndrome was made; however, he improved clinically and eculizumab was not started. Workup for the atypical hemolytic uremic syndrome was unrevealing. The authors propose that the pancreatitis triggered a secondary TMA, which although rare, has previously been described in the literature. This case illustrates the diagnostic and therapeutic challenges associated with TMAs.
- Published
- 2020