1. Epstein-Barr Virus Associated Hodgkin Lymphoma in a 9-Year-Old Girl Receiving Long-Term Methotrexate Therapy for Juvenile Idiopathic Arthritis
- Author
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Masue Imaizumi, Junji Takeyama, Atsushi Sato, Kyoko Nakano, Ryo Ichinohazama, and Daiki Abukawa
- Subjects
musculoskeletal diseases ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Arthritis ,medicine.disease_cause ,Gastroenterology ,Virus ,Naproxen ,Pharmacotherapy ,immune system diseases ,Prednisone ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Child ,skin and connective tissue diseases ,Chemotherapy ,business.industry ,Hematology ,medicine.disease ,Hodgkin Disease ,Epstein–Barr virus ,Arthritis, Juvenile ,Tumor Virus Infections ,Methotrexate ,Oncology ,Pediatrics, Perinatology and Child Health ,Monoclonal ,Drug Therapy, Combination ,Female ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
We describe a case of Hodgkin lymphoma developing in a 9-year-old girl with polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis treated with methotrexate (MTX), prednisone, and naproxen for 5 years. Pathologic and molecular analyses revealed that the Hodgkin cells contained Epstein-Barr virus and the viral DNA was monoclonal. She achieved complete remission after MTX withdrawal, chemotherapy, and radiation. To the best of my knowledge, this is the sixth report of Hodgkin lymphoma in patients with juvenile idiopathic arthritis receiving low dose MTX therapy.
- Published
- 2006
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