7 results on '"Pablo J. Sánchez"'
Search Results
2. Timing of newborn hearing screening in the neonatal intensive care unit: implications for targeted screening for congenital cytomegalovirus infection
- Author
-
Cory T Hanlon, Masako Shimamura, Amy Leber, Ursula M Findlen, Holly Gerth, Alexandra K Medoro, Douglas Salamon, Nicholas Foor, Pablo J. Sánchez, Prashant S. Malhotra, Gina Hounam, and Oliver F. Adunka
- Subjects
Pediatrics ,medicine.medical_specialty ,Neonatal intensive care unit ,business.industry ,Hearing loss ,MEDLINE ,Congenital cytomegalovirus infection ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Hearing screening ,Pediatrics, Perinatology and Child Health ,otorhinolaryngologic diseases ,Medicine ,Gestation ,Targeted screening ,medicine.symptom ,business - Abstract
To determine when infants in the neonatal intensive care unit (NICU) have the first hearing screen performed, and thus inform targeted testing for cytomegalovirus (CMV)-related hearing loss. Retrospective review of electronic health records of infants admitted to a Level 4 outborn NICU and had a first hearing screen performed from 8/2016–8/2018. Among 1498 infants, 546 (36%) had a first hearing screen performed at age >21 days when a positive CMV PCR test cannot distinguish congenital from postnatal CMV acquisition. While most infants tested at >21 days of age were
- Published
- 2020
- Full Text
- View/download PDF
3. Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection
- Author
-
Lizette Lee, Liliana N. Vazquez, Fiker Zeray, Fabiana Garcia, Pablo J. Sánchez, Andrea Ronchi, Joseph B. Cantey, Shawn Varghese, Lorenza Pugni, Angela G. Shoup, Fabio Mosca, and Kris E. Owen
- Subjects
Male ,medicine.medical_specialty ,Anemia ,Hearing Loss, Sensorineural ,Gestational Age ,Neuroimaging ,Physical examination ,Antiviral Agents ,Gastroenterology ,Asymptomatic ,Article ,03 medical and health sciences ,Medical research ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Valganciclovir ,030212 general & internal medicine ,Signs and symptoms ,Ganciclovir ,Physical Examination ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Chorioretinitis ,Brain ,Obstetrics and Gynecology ,Gestational age ,Alanine Transaminase ,medicine.disease ,Thrombocytopenia ,Blood Cell Count ,Intraventricular hemorrhage ,Cytomegalovirus Infections ,Pediatrics, Perinatology and Child Health ,Female ,Sensorineural hearing loss ,Abnormality ,medicine.symptom ,business - Abstract
Objective To determine the frequency of abnormal findings on evaluation of neonates with congenital CMV infection who have a normal physical examination Study design Retrospective, 2-center study (1996–2017) that reviewed results of complete blood cell count and platelets, serum alanine aminotransferase (ALT) and bilirubin concentrations, eye examination, cranial ultrasonography or other neuroimaging, and brainstem evoked responses performed on neonates with congenital CMV infection and a normal physical examination Results Of 34 infants with congenital CMV infection and a normal physical examination, 56% (19/34) had ≥1 abnormality: 39%, elevated ALT concentration; 45%, abnormal neuroimaging (five, lenticulostriate vasculopathy; six, intraventricular hemorrhage; four, calcifications); 12%, anemia; 16%, thrombocytopenia; and 3%, chorioretinitis. Seven (21%) infants had sensorineural hearing loss, and 18 infants received antiviral therapy. Conclusion Some infants with congenital CMV infection and a normal physical examination had abnormalities on laboratory or neuroimaging evaluation, which in some cases prompted antiviral treatment.
- Published
- 2019
- Full Text
- View/download PDF
4. Inadequate oral feeding as a barrier to discharge in moderately preterm infants
- Author
-
Shampa Saha, Ronald N. Goldberg, Pablo J. Sánchez, Edward F. Bell, Laura F. Edwards, Abhik Das, C. Michael Cotten, Barbara J. Stoll, Seetha Shankaran, Waldemar A. Carlo, Michele C. Walsh, P. Brian Smith, Betty R. Vohr, Sara B. DeMauro, Carl T. D'Angio, William F. Malcolm, Abbot R. Laptook, and Krisa P. Van Meurs
- Subjects
Male ,medicine.medical_specialty ,Pediatrics ,Logistic regression ,Article ,Feeding Methods ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Feeding behavior ,030225 pediatrics ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Respiratory Distress Syndrome, Newborn ,business.industry ,Infant, Newborn ,Postmenstrual Age ,Infant ,Obstetrics and Gynecology ,Feeding Behavior ,medicine.disease ,Patient Discharge ,Bottle Feeding ,Breast Feeding ,Logistic Models ,Pediatrics, Perinatology and Child Health ,Female ,Outcomes research ,Energy Intake ,business ,Breast feeding ,Infant, Premature ,Oral feeding - Abstract
The objectives describe the frequency that inadequate oral feeding (IOF) is the reason why moderately preterm (MPT) infants remain hospitalized and its association with neonatal morbidities. Prospective study using the NICHD Neonatal Research Network MPT Registry. Multivariable logistic regression was used to describe associations between IOF and continued hospitalization at 36 weeks postmenstrual age (PMA). A total of 6017 MPT infants from 18 centers were included. Three-thousand three-seventy-six (56%) remained hospitalized at 36 weeks PMA, of whom 1262 (37%) remained hospitalized due to IOF. IOF was associated with RDS (OR 2.02, 1.66–2.46), PDA (OR 1.86, 1.37–2.52), sepsis (OR 2.36, 95% 1.48–3.78), NEC (OR 16.14, 7.27–35.90), and BPD (OR 3.65, 2.56–5.21) compared to infants discharged and was associated with medical NEC (OR 2.06, 1.19–3.56) and BPD (OR 0.46, 0.34–0.61) compared to infants remaining hospitalized for an alternative reason. IOF is the most common barrier to discharge in MPT infants, especially among those with neonatal morbidities.
- Published
- 2019
- Full Text
- View/download PDF
5. Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III
- Author
-
Michael C. Morriss, Roy J. Heyne, Lina F. Chalak, Tara L. DuPont, Pablo J. Sánchez, Ashley M. Lucke, and Nancy K. Rollins
- Subjects
Male ,medicine.medical_specialty ,Pediatrics ,Developmental Disabilities ,Population ,Bayley-scores ,Neonatal encephalopathy ,Article ,neurodevelopmental outcomes ,Cohort Studies ,03 medical and health sciences ,Child Development ,0302 clinical medicine ,Hypothermia, Induced ,Predictive Value of Tests ,030225 pediatrics ,Outcome Assessment, Health Care ,Humans ,Medicine ,Neonatology ,Prospective cohort study ,education ,education.field_of_study ,business.industry ,Infant, Newborn ,Infant ,Obstetrics and Gynecology ,Gestational age ,Hypothermia ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Predictive value of tests ,Hypoxia-Ischemia, Brain ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,hypothermia ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia. We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005–November 2011. Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III
- Published
- 2014
- Full Text
- View/download PDF
6. Persistence of herpes simplex virus DNA in cerebrospinal fluid of neonates with herpes simplex virus encephalitis
- Author
-
Pablo J. Sánchez, Monica I. Ardura, Asuncion Mejias, R. Bustos, and Charina M. Ramirez
- Subjects
Adult ,Male ,Simplexvirus ,food.ingredient ,viruses ,Acyclovir ,medicine.disease_cause ,Antiviral Agents ,Polymerase Chain Reaction ,Drug Administration Schedule ,law.invention ,Encephalomalacia ,Cerebrospinal fluid ,food ,Pregnancy ,law ,medicine ,Humans ,Aciclovir ,Polymerase chain reaction ,Retrospective Studies ,Dose-Response Relationship, Drug ,business.industry ,Infant, Newborn ,Brain ,Infant ,Obstetrics and Gynecology ,Viral Load ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,Virology ,Herpes simplex virus ,Viral replication ,DNA, Viral ,Pediatrics, Perinatology and Child Health ,Immunology ,Brain Damage, Chronic ,Female ,Encephalitis, Herpes Simplex ,Atrophy ,Tomography, X-Ray Computed ,business ,Viral load ,Encephalitis ,medicine.drug - Abstract
The significance of detecting herpes simplex virus (HSV) DNA in the cerebrospinal fluid (CSF) of infants with HSV encephalitis after receipt of prolonged therapy with high-dose (60 mg kg(-1) day(-1)) acyclovir is unknown. We report the clinical and laboratory characteristics, neuroimaging studies and outcomes of four neonates with HSV encephalitis who had persistence of CSF HSV DNA, by polymerase chain reaction (PCR) after 15 to 21 days of high-dose acyclovir therapy.Retrospective chart review.All four infants had abnormal neuroimaging studies and subsequently experienced severe developmental delay or death.A persistently positive CSF HSV PCR in neonates may be another risk factor for worse neurodevelopmental outcome. Prospective studies are needed to document how often HSV DNA persists in CSF, elucidate whether it represents an initially high CSF viral load, ongoing viral replication or viral resistance, and determine its possible association with neurodevelopmental impairment.
- Published
- 2009
- Full Text
- View/download PDF
7. Nosocomial Infection in the NICU: A Medical Complication or Unavoidable Problem?
- Author
-
Daniel K. Benjamin, Richard Powers, Pablo J. Sánchez, Barry T. Bloom, Reese H. Clark, and Robert D. White
- Subjects
medicine.medical_specialty ,Neonatal intensive care unit ,medicine.drug_class ,Antibiotics ,Sepsis ,Risk Factors ,Intensive Care Units, Neonatal ,Intensive care ,medicine ,Humans ,Diagnostic Errors ,Antibiotic use ,Intensive care medicine ,Cross Infection ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Bacterial Infections ,medicine.disease ,Low birth weight ,Mycoses ,Pediatrics, Perinatology and Child Health ,medicine.symptom ,business ,Complication ,Hospital stay - Abstract
Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care. As it is associated with increases in mortality, morbidity, and prolonged length of hospital stay, both the human and fiscal costs of these infections are high. Although the rate of nosocomial sepsis increases with the degree of both prematurity and low birth weight, no specific lab test has been shown to be very useful in improving our ability to predict who has a "real" blood-stream infection and, therefore, who needs to be treated with a full course of antibiotics. As a result, antibiotic use is double the rate of "proven" sepsis and we are facilitating the growth of resistant organisms in the neonatal intensive care unit. The purpose of this article is to review the topic of nosocomial infections in neonates.
- Published
- 2004
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.