Search

Your search keyword '"Adriano Araújo"' showing total 3 results
Start Over Author "Adriano Araújo" Journal journal of periodontology
3 results on '"Adriano Araújo"'

1. Dry Extract of Matricaria recutita L. (Chamomile) Prevents Ligature-Induced Alveolar Bone Resorption in Rats via Inhibition of Tumor Necrosis Factor-α and Interleukin-1β

Author

Mariana Vasconcelos Guimarães, Vilma Lima, Deizy Viviana Tenazoa Wong, Vilana Maria Adriano Araújo, Ronaldo A. Ribeiro, Cristiane Sá Roriz Fonteles, Luzia Kalyne Almeida Moreira Leal, and Iracema Matos Melo

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Matricaria, Interleukin-1beta, Alveolar Bone Loss, Osteoclasts, Bone resorption, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Osteoprotegerin, Internal medicine, Medicine, Animals, Bone Resorption, Rats, Wistar, Periodontitis, biology, business.industry, Plant Extracts, Tumor Necrosis Factor-alpha, RANK Ligand, Acid phosphatase, Interleukin, Chamomile, 030206 dentistry, biology.organism_classification, Resorption, Rats, 030104 developmental biology, Endocrinology, RANKL, biology.protein, Periodontics, business
Abstract

Matricaria recutita L. (chamomile) has demonstrated anti-inflammatory activity. Accordingly, the ability of the Matricaria recutita extract (MRE) to inhibit proinflammatory cytokines and its influence on alveolar bone resorption (ABR) in rats.Wistar rats were subjected to ABR by ligature with nylon thread in the second upper-left molar, with contralateral hemiarcade as control. Rats received polysorbate TW80 (vehicle) or MRE (10, 30, and 90 mg/kg) 1 hour before ligature and daily until day 11. The periodontium was analyzed by macroscopy, histometry, histopathology, and immunohistochemistry for the receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), and tartrate-resistant acid phosphatase (TRAP). The gingival tissue was used to quantify the myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels by enzyme-linked immunosorbent assay. Blood samples were collected to evaluate bone-specific alkaline phosphatase (BALP), leukogram, and dosages of aspartate and alanine transaminases, urea, and creatinine. Aspects of liver, kidneys, spleen, and body mass variations were also evaluated.The 11 days of ligature induced bone resorption, low levels of BALP, leukocyte infiltration; increase of MPO, TNF-α, and IL-1β; immunostaining increase for RANKL and TRAP; reduction of OPG and leukocytosis, which were significantly prevented by MRE, except for the low levels of BALP and the leukocytosis. Additionally, MRE did not alter organs or body weights of rats.MRE prevented the inflammation and ABR by reducing TNF-α and IL-1β, preventing the osteoclast activation via the RANKL-OPG axis, without interfering with bone anabolism.

Published
2016

2. Dry Extract of Matricaria recutita L. (Chamomile) Prevents Ligature-Induced Alveolar Bone Resorption in Rats via Inhibition of Tumor Necrosis Factor-α and Interleukin-1β.

Author

Guimarães, Mariana Vasconcelos, Melo, Iracema Matos, Adriano Araújo, Vilana Maria, Tenazoa Wong, Deizy Viviana, Roriz Fonteles, Cristiane Sá, Moreira Leal, Luzia Kalyne Almeida, Ribeiro, Ronaldo Albuquerque, Lima, Vilma, Guimarães, Mariana Vasconcelos, Adriano Araújo, Vilana Maria, and Roriz Fonteles, Cristiane Sá

Abstract

Background: Matricaria recutita L. (chamomile) has demonstrated anti-inflammatory activity. Accordingly, the ability of the Matricaria recutita extract (MRE) to inhibit proinflammatory cytokines and its influence on alveolar bone resorption (ABR) in rats.Methods: Wistar rats were subjected to ABR by ligature with nylon thread in the second upper-left molar, with contralateral hemiarcade as control. Rats received polysorbate TW80 (vehicle) or MRE (10, 30, and 90 mg/kg) 1 hour before ligature and daily until day 11. The periodontium was analyzed by macroscopy, histometry, histopathology, and immunohistochemistry for the receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), and tartrate-resistant acid phosphatase (TRAP). The gingival tissue was used to quantify the myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels by enzyme-linked immunosorbent assay. Blood samples were collected to evaluate bone-specific alkaline phosphatase (BALP), leukogram, and dosages of aspartate and alanine transaminases, urea, and creatinine. Aspects of liver, kidneys, spleen, and body mass variations were also evaluated.Results: The 11 days of ligature induced bone resorption, low levels of BALP, leukocyte infiltration; increase of MPO, TNF-α, and IL-1β; immunostaining increase for RANKL and TRAP; reduction of OPG and leukocytosis, which were significantly prevented by MRE, except for the low levels of BALP and the leukocytosis. Additionally, MRE did not alter organs or body weights of rats.Conclusion: MRE prevented the inflammation and ABR by reducing TNF-α and IL-1β, preventing the osteoclast activation via the RANKL-OPG axis, without interfering with bone anabolism. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

3. Dry Extract of Matricaria recutitaL. (Chamomile) Prevents Ligature‐Induced Alveolar Bone Resorption in Rats via Inhibition of Tumor Necrosis Factor‐α and Interleukin‐1β

Author

Guimarães, Mariana Vasconcelos, Melo, Iracema Matos, Adriano Araújo, Vilana Maria, Tenazoa Wong, Deizy Viviana, Roriz Fonteles, Cristiane Sá, Moreira Leal, Luzia Kalyne Almeida, Ribeiro, Ronaldo Albuquerque, and Lima, Vilma

Abstract

Background:Matricaria recutitaL. (chamomile) has demonstrated anti‐inflammatory activity. Accordingly, the ability of the Matricaria recutitaextract (MRE) to inhibit proinflammatory cytokines and its influence on alveolar bone resorption (ABR) in rats. Methods:Wistar rats were subjected to ABR by ligature with nylon thread in the second upper‐left molar, with contralateral hemiarcade as control. Rats received polysorbate TW80(vehicle) or MRE (10, 30, and 90 mg/kg) 1 hour before ligature and daily until day 11. The periodontium was analyzed by macroscopy, histometry, histopathology, and immunohistochemistry for the receptor activator of nuclear factor‐kappa B ligand (RANKL), osteoprotegerin (OPG), and tartrate‐resistant acid phosphatase (TRAP). The gingival tissue was used to quantify the myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)‐α and interleukin (IL)‐1β levels by enzyme‐linked immunosorbent assay. Blood samples were collected to evaluate bone‐specific alkaline phosphatase (BALP), leukogram, and dosages of aspartate and alanine transaminases, urea, and creatinine. Aspects of liver, kidneys, spleen, and body mass variations were also evaluated. Results:The 11 days of ligature induced bone resorption, low levels of BALP, leukocyte infiltration; increase of MPO, TNF‐α, and IL‐1β; immunostaining increase for RANKL and TRAP; reduction of OPG and leukocytosis, which were significantly prevented by MRE, except for the low levels of BALP and the leukocytosis. Additionally, MRE did not alter organs or body weights of rats. Conclusion:MRE prevented the inflammation and ABR by reducing TNF‐α and IL‐1β, preventing the osteoclast activation via the RANKL–OPG axis, without interfering with bone anabolism.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results