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Assessing, predicting, and controlling injection-induced seismicity is a major challenge for developing enhanced geothermal systems (EGS) due to the complexity of coupled thermo-hydro-mechanical (THM) processes. This study aimed to develop a fully coupled numerical model to assess the complex behavior of a low permeable matrix-fracture during non-isothermal single-phase fluid injection process. A thermo-poroelastic displacement discontinuity (DD) method combining with different forms of finite element method are implemented to encapsulate the fractured medium response and transport processes, respectively. The nonlinear characteristics of normal (changing the joint to hydraulic fracture status) and shear (changing the stick to slip fracture status) fracture deformation are taken into account through fracture constitutive relations. Developed numerical approach was applied to simulate cool water injection into fracture/matrix systems, analyzing the role of coupled processes on spatiotemporal variation of matrix-fracture stresses, temperature and pore pressure and assessing induced seismicity (slippage) and permeability alteration. Numerical simulations demonstrate a fully coupled relation between matrix dilation, shrinkage, and non-linear fracture deformation. The redistribution of dynamic and kinematic parameters along with non-linear fracture deformation showed that although the poroelastic effects are dominant in the early stages, thermoelastic effects dominate in the long-term injection stages. • A fully-coupled Thermo-Hydro-Mechanical approach was developed to model injection process in EGS. • Displacement discontinuity and finite element methods were combined to encapsulate fracture deformation and transport processes, respectively. • Fracture constitutive laws were implemented to model non-linear crack deformation. • Poroelastic effects are dominant in the early stages, and thermoelastic effects dominate in the long-term injection stages. [ABSTRACT FROM AUTHOR]