Descriptor: "Chlorthalidone analysis" / Journal: journal of pharmaceutical sciences - Searchworks@Jio Institute Digital Library Search Results

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Start Over Descriptor "Chlorthalidone analysis" Journal journal of pharmaceutical sciences

Author: Bauer J, Quick J, Krogh S, and Shada D
Subjects: Chromatography, High Pressure Liquid methods, Drug Stability, Pharmacopoeias as Topic, Tablets analysis, Time Factors, United States, Chlorthalidone analysis
Abstract: An investigation of the USP assay of chlorthalidone tablets showed that variable degradation of chlorthalidone occurred during assay preparation. The degradation products were isolated and identified. A stability-indicating high-performance liquid chromatographic (HPLC) assay which separates the degradation products from chlorthalidone was developed and used to examine the present USP preparation. The HPLC assay is suggested as an alternate.
Published: 1983
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Author: Tweeddale MG and Ogilvie RI
Subjects: Adult, Chlorthalidone blood, Deamination, Erythrocytes analysis, Hemolysis, Humans, Male, Mass Spectrometry, Methods, Spectrophotometry, Ultraviolet, Body Fluids analysis, Chlorthalidone analysis
Published: 1974
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Author: O'Hare MJ, Tan E, and Moody JE
Subjects: Chromatography, High Pressure Liquid, Drug Combinations, Methods, Reserpine, Spectrophotometry, Ultraviolet, Tablets analysis, Chlorthalidone analysis
Abstract: A reliable and selective high-pressure liquid chromatographic procedure for the quantitative determination of chlorthalidone in pharmaceutical dosage forms is described. A comparison of this stability-indicating procedure with the USP spectrophotometric assay is presented for chlorthalidone tablets and chlorhalidone tablets containing reserpine.
Published: 1979
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