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Start Over Author "Teruaki Katayama" Journal journal of pharmacobio-dynamics
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1. Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen

Author

Sadahiko Ishibashi, Toshiaki Ohtsuka, Kazue Omura, Teruaki Katayama, Hiroyuki Masayasu, Shigemi Ichikawa, and Naoki Okamura

Subjects
Azoles, Neutrophils, Guinea Pigs, Granulocyte, In Vitro Techniques, Isoindoles, Antioxidants, Guinea pig, chemistry.chemical_compound, Selenium, Superoxides, Organoselenium Compounds, medicine, Animals, Pharmacology, integumentary system, Ebselen, Superoxide, Metabolism, Glutathione, In vitro, medicine.anatomical_structure, chemistry, Biochemistry, Phorbol, NADP
Abstract

Production of superoxide anion (O-2) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O-2 production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.

Published
1987

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