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Your search keyword '"Dahlbom R"' showing total 5 results
Start Over Author "Dahlbom R" Journal journal of pharmacy and pharmacology
5 results on '"Dahlbom R"'

1. Synthesis and pharmacology of 1-(2-thioxopyrrolidino)-4-pyrrolidino-2-butyne, the thiolactam analogue of oxotremorine

Author

LINDEKE, B, KARLÉN, B, DAHLBOM, R, GREEN, R, and JENDEN, D J

Abstract

The thiolactam analogue of oxotremorine (I) has been prepared and examined for muscarinic activity in mice and on guinea-pig ileal preparations. It is inactive in itself, but is transformed in vivoto oxotremorine (II), which has been identified in the urine of mice. The urine also contains 1-(2-oxopyrrolidino)-4-pyrrolidino-2-butanone (III) which is formed non-enzymatically from I under acidic conditions, but does not display any acetylcholine-like properties in vivoor in vitro.Oxotremorine is not formed from I in vitro.

Published
1972
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5. Stereoselectivity of some oxotremorine antagonists containing two chiral centres.

Author

Ringdahl B, Resul B, and Dahlbom R

Subjects
Animals, Atropine pharmacology, Male, Mice, Molecular Conformation, Mydriatics, Oxotremorine analogs & derivatives, Stereoisomerism, Tremor chemically induced, Oxotremorine antagonists & inhibitors
Abstract

The stereoisomers of some analogues of oxotremorine containing two chiral centres, one in the 1-position of the butynyl chas are oxotremorine antagonists. They show a marked stereoselectivity, which depends mainly on the configuration of the chiral centre in the butynyl chain and to a lesser extent on the configuration of that in the pyrrolidine ring.

Published
1979
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