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A new simple Schiff-base ligand 2-Hydroxy-1-naphthaldehyde-(2-pyridyl) hydrazone (HL) was synthesized and characterized as a fluorescent probe. In aqueous solution containing 10% ethanol (Hexamethylenetetramine-HCl buffer, pH5.3), HL selectively binds Al 3+ to form a 1:1 ligand/metal complex, resulting in a color change from colorless to yellow–green and a significant fluorescence enhancement at 454 nm. The addition of EDTA quenches fluorescence of the HL·Al 3+ complex, indicating that HL serves as a reversible chemosensor for Al 3+ . Under the optimum conditions, the dynamic range of the system was found to be linear up to 4.0 × 10 −6 M Al 3+ ions with a limit of detection of 36.6 nM. The probe is very effective for detection of intracellular Al 3+ through fluorescence microscopic imaging. [ABSTRACT FROM AUTHOR]

• Probe FL can display selectivity toward Cu+2 over other ions in DMSO/water (2/8, v/v) and showed an obvious color change. • Probe FL can operate in a wide range of pH. • The living cell image experiments demonstrate probe FL could be used to detect intracellular Cu2+ in living cells. A novel fluorescent and colorimetric probe FL was designed and synthesized for selective Cu2+ detection in aqueous solutions. The detection limit of probe FL for Cu2+ was determined to be 1.09 μM. Furthermore, probe FL was successfully used to recognize Cu2+ in living cells, indicating its high potential in biological imaging applications. [ABSTRACT FROM AUTHOR]