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[Display omitted] • NIR sensor for high-sensitive and selective detection and removal Cu2+ in living cells and environment. • Phthalocyanine based dual fluorescence and colorimetric sensor. • NIR fluorescence and colorimetric changes through cis- / trans interconversion. • Binding mechanism towards Cu2+were systematically revealed. Cu2+ sensing and removal are of great significance for environment protection and human health. Herein, multifunctional Cu2+ sensor system for both detection and removal of intracellular and environmental Cu2+ based on trans/cis interconversion of silicon phthalocyanine (SiPc) was developed. This phthalocyanine based Cu2+ sensor shows remarkably dual-mode NIR fluorescence and colorimetric responses for recognition of Cu2+, resulting in insoluble chelate for Cu2+ removal as well as the extremely high anti-interference in the presence of various anions and cations. The binding mechanism and stoichiometry ratio were systematically revealed. Intracellular fluorescence imaging in MCF-7 cells demonstrated that Cu2+ could be efficiently detected in living cells and form insoluble chelate for clearance. As the result, this novel phthalocyanine based multifunctional sensor can be used for dual-mode NIR fluorescence/colorimetric detection and removal of Cu2+ in either complicated environment or biological systems. [ABSTRACT FROM AUTHOR]

A dual-site fluorescent probe based on naphthalimide and rhodamine was synthesized, which could rapidly and sensitively respond to H 2 S and Cu2+ with different fluorescence signals. [Display omitted] • The dual-responsive fluorescent probe (DTR-1) for detection of H 2 S and Cu2+ was developed. • DTR-1 could detect H 2 S and Cu2+ within 1 min. • The LOD for H 2 S and Cu2+ were calculated to be 0.035 μM and 0.16 μM, respectively. • DTR-1 was successfully applied to detect intracellular H 2 S and Cu2+. A highly selective and sensitive fluorescence probe (DTR-1) for simultaneously detecting H 2 S and Cu2+ with different fluorescence signals was synthesized. DTR-1 displayed remarkable fluorescence enhancement (560 nm, 34-fold) when H 2 S was added under excitation of 410 nm with the solution's color change from dark to green. The limit of detection (LOD) for H 2 S was calculated to be 0.035 µM. By contrast, the addition of Cu2+ enhanced obviously the emission intensity of DTR-1 with the maximal peak at 630 nm and color change from colorless to orange. LOD for Cu2+ was determined to be 0.16 µM. The sensing mechanism for H 2 S and Cu2+ in DMF/PBS (9/1, v/v, pH = 7.4) was studied by 1H NMR and ESI-MS. Furthermore, the potential application of DTR-1 in biological systems had been demonstrated through imaging of living cells. [ABSTRACT FROM AUTHOR]

• BHMBH with benzothiazole fluorophore was synthesized and characterized. • BHMBH exhibits highly sensitivity fluorescence enhancement to Al3+ along with color change. • Limit of detection (LOD) for Al3+ was reached the level of 10−7 M. • BHMBH was successfully applied in the detection of Al3+ on test paper and imaging in HSC. An easy prepared benzothiazole-based probe (E)-5-(benzo[d]thiazol-2-yl)-2-hydroxy-3- methoxybenzaldehyde benzoyl hydrazone (BHMBH) was designed and synthesized, which displayed a significant fluorescence enhancement (over 500-fold) and obvious color changes in the recognition of Al3+. The binding ratio of probe BHMBH to Al3+ was determined as 1:1 according to Job's plot. The binding mechanism was fully clarified by the experiments such as FT-IR spectrum, ESI-MS analysis, and 1H NMR titration. The limit of detection (LOD) for Al3+ was determined as low as 0.232 μM based on the fluorescence titration of BHMBH. Moreover, the results of real sample experiments including real water sample, test papers, and cell image were all well demonstrated that BHMBH was capable of sensing Al3+ in environmental and biological system as well. [ABSTRACT FROM AUTHOR]