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A fluorescent probe composed of BODIPY and 2,4-dinitrophenylhydrazine was designed for the detection of ClO − . The oxidizing reaction between probe and ClO − resulted in a distinct fluorescence enhancement together with a color variation from pink to orange. This probe showed excellent selectivity to ClO − among various ions including common reactive oxygen species and high sensitivity with a detection limit of 228 nM. A fast response (7 min) was observed, which made the probe a promising method in real-time detection. Furthermore, this probe was successfully applied to monitor ClO − in real-life water and living cells. [ABSTRACT FROM AUTHOR]