1. Modified drug release using atmospheric pressure plasma deposited siloxane coatings
- Author
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Sam Maher, V. J. Law, Malika Ardhaoui, Denis P. Dowling, Alan K. Keenan, and Charlie P. Stallard
- Subjects
010302 applied physics ,chemistry.chemical_classification ,Materials science ,Chromatography ,Acoustics and Ultrasonics ,Elution ,Substrate (chemistry) ,Atmospheric-pressure plasma ,02 engineering and technology ,Polymer ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Siloxane ,0103 physical sciences ,Drug delivery ,Polystyrene ,0210 nano-technology ,Layer (electronics) - Abstract
This pilot study evaluates the potential of atmospheric plasma polymerised coatings to modify the rate of drug release from polymeric substrates. The antibiotic rifampicin was deposited in a prototype multi-layer drug delivery system, consisting of a nebulized layer of active drug between a base layer of TEOS deposited on a plastic substrate (polystyrene) and an overlying layer of plasma polymerised PDMS. The polymerised TEOS and PDMS layers were deposited using a helium atmospheric plasma jet system. Elution of rifampicin was measured using UV–VIS spectroscopy, in addition to a antimicrobial well diffusion assay with an established indicator organism. The multi-layered plasma deposited coatings significantly extended the duration of release of the rifampicin from 24 h for the uncoated polymer to 144 h for the coated polymer.
- Published
- 2016
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