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Your search keyword '"Zawadzka, Anna"' showing total 4 results
Start Over Author "Zawadzka, Anna" Journal journal of pineal research
4 results on '"Zawadzka, Anna"'

4. Highly selective inhibition of butyrylcholinesterase by a novel melatonin-tacrine heterodimers.

Author

Zawadzka, Anna, Łozińska, Iwona, Molęda, Zuzanna, Panasiewicz, Mirosława, and Czarnocki, Zbigniew

Subjects
*BUTYRYLCHOLINESTERASE, *MELATONIN, *HETERODIMERS, *TACRINE, *CHEMICAL bonds
Abstract

Novel inhibitors of cholinesterases, especially butyrylcholinesterase(BuChE), were obtained by coupling melatonin-tacrine heterodimersvia the carbamate bond. Compounds 14a-i possessed potent cholinesterase inhibitory activity (with IC50 values as low as 1.18 nM for acetylcholinesterase (AChE) and 0.24 nM for butyrylcholinesterase (BuChE)). These heterodimers exhibit selectivity toward BuChE, being from 4- to 256-fold more active toward BuChE than AChE, but still acting as better AChE inhibitors than tacrine 4. [ABSTRACT FROM AUTHOR]

Published
2013
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