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Since the start of the wars in Afghanistan and Iraq, there have been 866 major limb amputations from combat operations seen at major military medical centers in the United States. These injuries have challenged rehabilitation professionals with many clinical problems. One such challenge is treating patients who sustain multiple limb amputations that involve both an upper extremity (UE) and a lower extremity (LE). This uncommon amputation pattern describes 27 patients of the aforementioned total. This article is a case study of a multiple limb amputee whose primary rehabilitation goal was to walk without the aid of an assistive devise. The primary objective is to discuss how wearing a UE prosthesis affects gait in comparison with not wearing the prosthesis. There were notable temporal-spatial and kinematic differences in the patient's gait while wearing the UE prosthesis when compared with walking without it. For example, while wearing the UE prosthesis, the patient's trunk rotated more toward his intact side but lateral flexion became more symmetric. For this patient, wearing a UE prosthesis had a desirable effect on trunk kinematics while ambulating. [ABSTRACT FROM AUTHOR]