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Various data-driven voxel-wise measures derived from resting-state functional magnetic resonance imaging (rs-fMRI) have been developed to characterize spontaneous brain activity. These measures have been widely applied to explore brain functional changes in schizophrenia and have enjoyed significant success in unraveling the neural mechanisms of this disorder. However, their spatial and temporal coupling alterations in schizophrenia remain largely unknown. To address this issue, 88 schizophrenia patients and 116 gender- and age-matched healthy controls underwent rs-fMRI examinations. Kendall's W was used to calculate volume-wise (across voxels) and voxel-wise (across time windows) concordance among multiple commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity, voxel-mirrored homotopic connectivity, degree centrality and global signal connectivity. Inter-group differences in the concordance were investigated. Results revealed that whole gray matter volume-wise concordance was reduced in schizophrenia patients relative to healthy controls. Although two groups showed similar spatial distributions of the voxel-wise concordance, quantitative comparison analysis revealed that schizophrenia patients exhibited decreased voxel-wise concordance in gray matter areas spanning the bilateral frontal, parietal, occipital, temporal and insular cortices. In addition, these concordance changes were negatively correlated with onset age in schizophrenia patients. Our findings suggest that the concordance approaches may provide new insights into the neural mechanisms of schizophrenia and have the potential to be extended to neuropsychiatric disorders., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

There is evidence that major depressive disorder (MDD) is related to serum lipid level alterations. However, the neural correlates underlying this association remain poorly understood. Forty-nine patients with MDD and fifty healthy controls (HCs) underwent structural, resting-state functional and diffusion magnetic resonance imaging scans. Voxel-based morphometry, functional connectivity (FC) and tract-based spatial statistics analyses were performed to assess brain structure and function, respectively. Blood samples were collected to measure serum levels of lipid variables including total cholesterol, triglyceride and high density lipoprotein cholesterol (HDL-C). Correlation and mediation analyses were conducted to investigate the associations of serum lipid levels with brain imaging measures in MDD patients and HCs, respectively. We found that the serum HDL-C level in MDD patients was lower than that in HCs. The lower serum HDL-C level was associated with lower gray matter volume (GMV) in ventromedial prefrontal cortex (VMPFC), higher within-network FC of the default mode network, and lower micro-structural integrity in multiple white matter regions in MDD patients. Moreover, the within-default mode network FC mediated the relationship between GMV in VMPFC and serum HDL-C level; white matter integrity in genu of corpus callosum mediated the relationship between serum HDL-C level and depressive symptom severity. However, we did not observe any correlations between serum lipids and brain imaging parameters in HCs. These findings help to identify neural correlates underlying the association between depression and serum HDL-C change, which may provide new insight into intervention, treatment and prevention of depression from the perspective of regulating serum lipids. • Depression patients had lower serum high density lipoprotein cholesterol level. • It was associated with lower gray matter volume in ventromedial prefrontal cortex. • It was associated with higher functional connectivity in default mode network. • It was associated with lower micro-structural integrity in multiple white matter regions. • Mediation relationships were observed between serum lipid, brain, depressive symptom. [ABSTRACT FROM AUTHOR]