1. A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort.
- Author
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Li, Chun'e, Liang, Xiao, Cheng, Shiqiang, Wen, Yan, Pan, Chuyu, Zhang, Huijie, Chen, Yujing, Zhang, Jingxi, Zhang, Zhen, Yang, Xuena, Meng, Peilin, and Zhang, Feng
- Subjects
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ANXIETY , *MENTAL depression , *LINKAGE disequilibrium , *GENE frequency , *HERITABILITY - Abstract
The effects of gene-by-environment (G×E) interactions on complex diseases are significant, especially the superimposed effects of multiple environmental factors. However, research on the multi-environments-gene interactions of anxiety, depression, and self-harm is still limited. This study included white individuals (N = 66,041–74,482) from the UK Biobank. We fitted all environmental factors to a single environmental score (ES), and the estimated ES was used to calculate the multiplicative interaction effects between ES and genome-wide SNPs. Heritability was stratified by minor allele frequency (MAF) and linkage disequilibrium (LD). Our research found 10 loci with significant interaction effects, such as rs114830993 (PRICKLE2, P = 2.30 × 10−8), rs151323364 (ASTN2, P = 2.71 × 10−10) and rs536631793 (SYN3, P = 4.09 × 10−8). In addition, we found that G×E heritability has a significant contribution to the depression of Patient Health Questionnaire-9 (PHQ-9) scores (h2 G×E (female) = 6.1%, h2 G×E (male) = 8.7%). Our research supported the important influence of multi-environments-gene interactions on anxiety, depression, and self-harm and provided clues for the prevention and etiological research of them. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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