1. 213Bi production and complexation with new picolinate containing ligands.
- Author
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Sinenko, I. L., Kalmykova, T. P., Likhosherstova, D. V., Egorova, B. V., Zubenko, A. D., Vasiliev, A. N., Ermolaev, S. V., Lapshina, E. V., Ostapenko, V. S., Fedorova, O. A., and Kalmykov, S. N.
- Subjects
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BLOOD proteins , *LIGANDS (Chemistry) , *BISMUTH - Abstract
Binding of bismuth cation with two newly synthesized picolinate containing acyclic (L1) and macrocyclic (L2) ligands was studied. Both ligands demonstrate complex formation with Bi3+ under ambient conditions with high complexation constants. Serum stability of the complexes was investigated in serum protein excess of 10- and 100-times. Experiments with no-carrier-added radiobismuth (207Bi and 213Bi) were performed. A one-column 225Ac/213Bi generator system, based on Ac resin (Triskem Inc.), was tested. The overall yield of 213Bi was exceeding 85% with 225Ac breakthrough below 10−4%. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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