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We investigated the student-teacher relationships (STRs) of 6-year-old children with (n=58) and without (n=82) intellectual disability (ID). We also examined early (age 3) and concurrent (age 6) child behavioral, self-regulatory, and social characteristics as predictors of age 6 STR quality. Children with ID experienced significantly poorer relationships with their teachers, marked by less closeness and more conflict and dependency, compared to typically developing children. This group difference was not accounted for entirely by IQ differences. Child characteristics and parent-child interactional variables at age 3 and 6 accounted for 53.5% of the variance in age 6 STR quality. The relation between ID status and STR quality was fully mediated by three child variables--global self-regulation at age 3, mother-reported behavior problems at age 6, and teacher-reported behavior problems at age 6- and was partially mediated by mother-reported behavior problems at age 3. Our findings demonstrate the importance of child behavioral and social characteristics in predicting relationships with teachers for children with and without ID.