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Your search keyword '"Wang, Saisai"' showing total 3 results
Start Over Author "Wang, Saisai" Language english Journal journal of separation science
3 results on '"Wang, Saisai"'

3. Pseudo‐allergic compounds screened from Shengmai injection by using high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry.

Author

Sun, Wei, Wang, Saisai, Liang, Peida, Zhou, Huaxin, Zhang, Liyang, Jia, Qianqian, Fu, Jia, Lv, Yanni, and Han, Shengli

Subjects
*CELL receptors, *LIQUID chromatography, *MASS spectrometry, *HIGH performance liquid chromatography, *G protein coupled receptors
Abstract

Adverse drug reactions of traditional Chinese medicine injection mainly manifested as pseudo‐allergic reactions. In the present study, ginsenoside Rd, Ro, and Rg3 were identified as pseudo‐allergic components in Shengmai injection by a high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography coupled online with high‐performance liquid chromatography and mass spectrometry. Their pseudo‐allergic activities were evaluated by in vitro and in vivo assay. The three compounds were further found to induce pseudo‐allergic reaction through Mas‐related G protein‐coupled receptor X2. Therefore, we concluded that ginsenoside Rd, Ro and Rg3 may be potential allergens that cause pseudo‐allergic reactions. This study might be helpful for the safe use of Shengmai injection. [ABSTRACT FROM AUTHOR]

Published
2021
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