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Your search keyword '"Yu, De-Quan"' showing total 2 results
Start Over Author "Yu, De-Quan" Journal journal of steroid biochemistry & molecular biology
2 results on '"Yu, De-Quan"'

1. Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents.

Author

Yu, Bin, Shi, Xiao-Jing, Qi, Ping-Ping, Yu, De-Quan, and Liu, Hong-Min

Subjects
*DRUG design, *STEROIDAL alkaloids, *OXINDOLES, *CHEMICAL synthesis, *CANCER cells, *CELL lines, ANTINEOPLASTIC agent development
Abstract

Highlights: [•] Two series of novel steroidal spiro-oxindoles were efficiently synthesized. [•] Most of these compounds exhibited broad-spectrum antiproliferative activities. [•] Some of them were more potent than 5-Fu against four human cancer cell lines. [•] Compound 3g showed good antiproliferative activity against SMMC-7721 (IC50 =0.71μM). [•] Compound 3n showed cell cycle arrest at G2/M phase and induced early apoptosis. [Copyright &y& Elsevier]

Published
2014
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