1. A novel preoperative risk score to optimize patient selection for performing concomitant liver resection with cytoreductive surgery/HIPEC
- Author
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Lee, Rachel M, Gamboa, Adriana C, Turgeon, Michael K, Zaidi, Mohammad Y, Kimbrough, Charles, Leiting, Jennifer, Grotz, Travis, Lee, Andrew J, Fournier, Keith, Powers, Benjamin, Dineen, Sean, Baumgartner, Joel M, Veerapong, Jula, Mogal, Harveshp, Clarke, Callisia, Wilson, Gregory, Patel, Sameer, Hendrix, Ryan, Lambert, Laura, Pokrzywa, Courtney, Abbott, Daniel E, LaRocca, Christopher J, Raoof, Mustafa, Greer, Jonathan, Johnston, Fabian M, Staley, Charles A, Cloyd, Jordan M, Maithel, Shishir K, and Russell, Maria C
- Subjects
Clinical Research ,Digestive Diseases ,Liver Disease ,Patient Safety ,Colo-Rectal Cancer ,Cancer ,Evaluation of treatments and therapeutic interventions ,6.4 Surgery ,Appendiceal Neoplasms ,Chemotherapy ,Cancer ,Regional Perfusion ,Colorectal Neoplasms ,Combined Modality Therapy ,Cytoreduction Surgical Procedures ,Female ,Follow-Up Studies ,Hepatectomy ,Humans ,Hyperthermia ,Induced ,Male ,Middle Aged ,Patient Selection ,Peritoneal Neoplasms ,Preoperative Care ,Prognosis ,Risk Factors ,Survival Rate ,appendiceal adenocarcinoma ,colorectal cancer ,HIPEC ,liver resection ,risk score ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundWhile parenchymal hepatic metastases were previously considered a contraindication to cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), liver resection (LR) is increasingly performed with CRS/HIPEC.MethodsPatients from the US HIPEC Collaborative (2000-2017) with invasive appendiceal or colorectal adenocarcinoma undergoing primary, curative intent CRS/HIPEC with CC0-1 resection were included. LR was defined as a formal parenchymal resection. Primary endpoints were postoperative complications and overall survival (OS).ResultsA total of 658 patients were included. About 83 (15%) underwent LR of colorectal (58%) or invasive appendiceal (42%) metastases. LR patients had more complications (81% vs. 60%; p = .001), greater number of complications (2.3 vs. 1.5; p
- Published
- 2021