18 results on '"R. Lor Randall"'
Search Results
2. The dynamic microenvironment associated with metastatic bone disease: Current concepts
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Rahul Bhale, Paramita Ghosh, Raminta Theriault, Steven Thorpe, Gabriela Loots, and R. Lor Randall
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Oncology ,Surgery ,General Medicine - Published
- 2023
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3. Impact of local treatment modality on overall‐ and disease‐specific survival for nonmetastatic pelvic and sacral Ewing sarcoma
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Muhammad Umar Jawad, Brad H. Pollock, Lauren N. Zeitlinger, Edmond F. O'Donnell, Sophia A. Traven, Janai R. Carr‐Ascher, Elysia Alvarez, Marcio H. Malogolowkin, Steven W. Thorpe, and R. Lor Randall
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Sacrum ,Oncology ,Humans ,Bone Neoplasms ,Radiotherapy, Adjuvant ,Surgery ,Prospective Studies ,Sarcoma, Ewing ,General Medicine ,Prognosis ,United States ,Retrospective Studies - Abstract
The ideal local treatment modality for pelvic and sacral Ewing sarcoma (EWS) is controversial.We present the data from the American College of Surgeon's National Cancer Database (NCDB) and the National Cancer Institute's Surveillance, Epidemiology and End Result (SEER) database to investigate the impact of local treatment modalities on survival for nonmetastatic pelvic and sacral Ewing sarcoma. Local treatment includes "surgery," "radiation," and a combination of "surgery and radiation."A total of 235 cases from SEER and 285 cases from NCDB were analyzed. Patients with "localized" stage (intraosseous) in the SEER database did not show any statistically significant difference in the disease-specific survival (DSS) for any of the local treatment modalities. Similar findings were observed for overall survival among patients with American Joint Committee on Cancer (AJCC) stage II and III in the NCDB database. However, patients with nonmetastatic disease, particularly regional disease (extraosseous), showed improved DSS with surgery only, in the SEER.We found similar levels of efficacy for different treatment modalities for patients with intraosseous and AJCC II and III pelvic and sacral EWS. "Radiotherapy" is the most common local treatment modality employed in the United States. A prospective, randomized controlled trial with a direct head-to-head comparison is needed for a definitive conclusion.
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- 2022
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4. Sex, racial/ethnic and socioeconomic disparities in patients with metastatic bone disease
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Muhammad Umar Jawad, Brad H. Pollock, Barton L. Wise, Lauren N. Zeitlinger, Edmond F. O’ Donnell, Janai R. Carr‐Ascher, Amy Cizik, Betty Ferrell, Steven W. Thorpe, and R. Lor Randall
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Urologic Diseases ,Oncology and Carcinogenesis ,Bone Neoplasms ,bone ,Article ,Sex Factors ,Ethnicity ,metastasis ,Humans ,Oncology & Carcinogenesis ,Healthcare Disparities ,Cancer ,Prevention ,Prostate Cancer ,Incidence ,Racial Groups ,dispartiy ,Health Status Disparities ,General Medicine ,Prognosis ,United States ,Colo-Rectal Cancer ,Social Class ,Socioeconomic Factors ,Oncology ,Surgery ,Digestive Diseases ,Follow-Up Studies - Abstract
BackgroundWe have analyzed sex, race/ethnicity or socioeconomic disparities in the incidence of metastatic bone disease (MBD).MethodsPatients with the diagnosis of MBD at presentation for five most common primary anatomical sites was extracted from Surveillance, Epidemiology, and End Results Census tract-level dataset. Mean incidence of MBD for different sex, racial/ethnic and socioeconomic groups were compared.ResultsThe five most common anatomical sites with MBD at presentation include "lung: (n = 59 739), "prostate" (n = 19 732), "breast" (n = 16 244), "renal" (n = 7718) and "colon" (n = 3068). There was an increase in incidence of MBD among cancers originating from prostate (annual percentage change [APC] 4.94), renal (APC 2.55), and colon (APC 3.21) (p
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- 2021
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5. Malignant neoplasms originating from the bones of the foot: Predilection of hematological malignancies and sex‐related and ethnic disparities in amputation
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Muhammad Umar Jawad, Saif Farhan, Max R. Haffner, Christopher Kreulen, Eric Giza, R. Lor Randall, and Steven W. Thorpe
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Population ,Bone Neoplasms ,Amputation, Surgical ,California ,Cohort Studies ,Foot Diseases ,Young Adult ,Sex Factors ,Neoplasms ,Internal medicine ,Epidemiology ,Ethnicity ,Chi-square test ,medicine ,Humans ,Child ,education ,Aged ,education.field_of_study ,Proportional hazards model ,business.industry ,Incidence ,Incidence (epidemiology) ,Infant, Newborn ,Infant ,General Medicine ,Middle Aged ,Prognosis ,Oncology ,Amputation ,Child, Preschool ,Hematologic Neoplasms ,Cohort ,Female ,Surgery ,business ,Foot (unit) ,Follow-Up Studies ,SEER Program - Abstract
PURPOSE Neoplasms originating from the "small bones of the lower limb and the overlapping joints" are rare but portend a serious prognosis. Current study utilizes a population-based registry in the United States to characterize the malignancies of the foot. METHODS National Cancer Institute's Surveillance, Epidemiology and End Result database from 1975 to 2017 was queried to report incidence and survival data in 514 patients in the Uited States. Kaplan-Meier and Cox Regression were used to determine the prognostic factors affecting survival. Chi square test was used to assess the correlation. RESULTS Hematological malignancies constituted 14.8% of the entire cohort. Incidence of the foot neoplasms was 0.024 per 100 000 persons in 2017 and has not significantly changed since 1975 (p > 0.05). Disease-specific-5-year survival for the entire cohort was 73%. On multivariate analysis younger age groups, "localized" stage and extent of surgical resection were predictors of improved outcomes. A significant correlation was found between amputation with male sex and Hispanic ethnicity. CONCLUSIONS The current study analyzes data from population-based registry reporting incidence and survival data for patients with neoplasms of the foot. Independent prognostic factors include age, stage and extent of surgical resection. Amputation was found to be associated with male sex and Hispanic ethnicity.
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- 2021
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6. Cover Image, Volume 126, Number 3, September 1, 2022
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Muhammad Umar Jawad, Brad H. Pollock, Lauren N. Zeitlinger, Edmond F. O'Donnell, Sophia A. Traven, Janai R. Carr‐Ascher, Elysia Alvarez, Marcio H. Malogolowkin, Steven W. Thorpe, and R. Lor Randall
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Oncology ,Surgery ,General Medicine - Published
- 2022
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7. Primary mobile vertebral column sarcomas: Prognostic factors vary by histologic subtypes
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Saif Farhan, Max R. Haffner, Eric O. Klineberg, Hai Van Le, R. Lor Randall, Steven W. Thorpe, and Muhammad Umar Jawad
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Adolescent ,Population ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Epidemiology ,medicine ,Humans ,Stage (cooking) ,Child ,education ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence ,Incidence (epidemiology) ,Infant, Newborn ,Infant ,Sarcoma ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Spine ,United States ,Survival Rate ,Child, Preschool ,030220 oncology & carcinogenesis ,Cohort ,Female ,030211 gastroenterology & hepatology ,Surgery ,Chondrosarcoma ,business ,Follow-Up Studies ,SEER Program - Abstract
Background Primary sarcomas originating from the mobile spine portends a particularly sinister outcome. Rarity of the disease process has resulted in inconsistent data due to small sample size and heterogeneity in patient selection and analytics. Methods Surveillance, Epidemiology and End Result (SEER) database from 1975 to 2017 was queried to report incidence and survival data in 712 patients in the United States. Kaplan-Meier and Cox Regression were used to determine the prognostic factors affecting survival. Results Incidence of spinal sarcoma was 0.019 per 100,000 persons in 2017 and has not significantly changed since 2000 (p > 0.05). Disease-specific 5-year survival for the entire cohort was 57%. Osteosarcoma has the worst 5-year survival (39%) and chondrosarcoma has the best 5-year survival (69%). Independent predictors of survival for the entire cohort included age, grade, and stage. Stage was an independent predictor of survival for every histologic subtype. Additional predictors of survival for spinal osteosarcoma, Ewing sarcoma, and chondrosarcoma included age, size, and grade, respectively. Conclusions The current study is an analysis of a population-based registry reporting incidence survival data for patients with sarcoma of mobile vertebral column. Survival and prognostic factors vary by histologic subtypes. There is lack of improvement in survival over the last three decades.
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- 2021
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8. Cover Image, Volume 125, Number 4, March 15, 2022
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Muhammad Umar Jawad, Brad H. Pollock, Barton L. Wise, Lauren N. Zeitlinger, Edmond F. O’ Donnell, Janai R. Carr‐Ascher, Amy Cizik, Betty Ferrell, Steven W. Thorpe, and R. Lor Randall
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Oncology ,Surgery ,General Medicine - Published
- 2022
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9. Opportunistic muscle measurements on staging chest CT for extremity and truncal soft tissue sarcoma are associated with survival
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Robert J. Canter, Augustine M. Saiz, Steven W. Thorpe, Leon Lenchik, Felix S. Wong, R. Lor Randall, Sandra L. Taylor, Eileen Phan, and Robert D. Boutin
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Male ,Aging ,Sarcopenia ,sarcoma ,Chest ct ,Kaplan-Meier Estimate ,0302 clinical medicine ,Tomography ,Cancer ,screening and diagnosis ,Univariate analysis ,Soft tissue sarcoma ,muscle metrics ,Hazard ratio ,Torso ,Sarcoma ,Skeletal ,General Medicine ,Middle Aged ,X-Ray Computed ,Survival Rate ,Detection ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Muscle ,Biomedical Imaging ,030211 gastroenterology & hepatology ,Female ,Radiology ,4.2 Evaluation of markers and technologies ,medicine.medical_specialty ,Oncology and Carcinogenesis ,Disease-Free Survival ,Article ,03 medical and health sciences ,Clinical Research ,myosteatosis ,medicine ,Humans ,In patient ,Oncology & Carcinogenesis ,Muscle, Skeletal ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Skeletal muscle ,Extremities ,medicine.disease ,Surgery ,business ,Tomography, X-Ray Computed - Abstract
Background and objectives Computed tomography (CT) measurements of sarcopenia have been proposed as biomarkers associated with outcomes in various cancers and have typically been evaluated at the L3 vertebral level. However, staging imaging for patients with extremity and truncal soft tissue sarcoma (STS) often only includes chest CT imaging which precludes evaluation at L3. Therefore, we sought to evaluate muscle metrics at T12 on standard staging chest CT scans and evaluate for correlation with overall and event-free survival in patients with STS. Methods CT chest imaging for 89 patients with intermediate and high-grade STS (53 male, 36 female; 58.5 ± 19.0 years old, follow-up 37.4 ± 27.1 months) was reviewed on PACS at T12 for skeletal muscle density (SMD) and skeletal muscle index (SMI). Results Overall survival increased with increased SMD on univariate (hazard ratio [HR] = 0.61 [0.43, 0.86]) and age-adjusted analysis (HR = 0.65 [0.42, 0.89]. Event-free survival also increased with increased SMD in univariate analyses (HR = 0.68 [0.49, 0.95]) but did not maintain significance after adjusting for age (HR = 0.68 [0.43, 1.07]). SMI was not a predictor of overall or event-free survival. Conclusions Higher SMD measured on routinely obtained staging chest CTs in STS patients is associated with improved survival.
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- 2020
10. PROMIS®scores in operative metastatic bone disease patients: A multicenter, prospective study
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Kevin B. Jones, Yue Zhang, Man Hung, Alan T. Blank, Wei Liu, Daniel M. Lerman, Sara Shaw, R. Lor Randall, and Farnaz Dadrass
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030222 orthopedics ,medicine.medical_specialty ,education.field_of_study ,Demographics ,Bone disease ,business.industry ,Population ,General Medicine ,Physical function ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Surgery ,Prospective cohort study ,business ,education ,Surgical treatment - Abstract
Background The prevalence of metastatic bone disease (MBD) grows each year as treatments improve. Little has been published about functional and pain outcomes in this group after surgery. Patient-Reported Outcomes Measurement Information System (PROMIS® ) can collect information, in just minutes, about patient's physical, mental, and social health. This study evaluated PROMIS® pain and functional scores in surgically treated patients with MBD. Methods Basic demographics and PROMIS® scores were recorded from a total of 13 patients at 9 periods of time over 6 months. Results The average change in physical function at week 1 was -2.5 (standard deviation [SD] = 5.4), at 2 weeks 1.7 (SD = 7.6), after 4 weeks 6.9 (SD = 10), after 6 weeks 6.4 (SD = 10.9), after 10 weeks 15.3 (SD = 3.1), and after 3 months 8.6 (SD = 7.6). The average change in pain inference at week 1 was -1.2 (SD = 7.3), at 2 weeks -2.1 (SD = 9.5), after 4 weeks -12.6 (SD = 4.5), after 6 weeks -8.3 (SD = 10.2), after 10 weeks -16.6 (SD = 4.3), and after 3 months -11.4 (SD = 8.2). Conclusions PROMIS® provides a feasible means to collect data in this population. Trends of improved function and decreased pain were seen after surgery. Continuing this study will hopefully elucidate more insight into the surgical treatment of MBD.
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- 2018
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11. PROMIS
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Alan T, Blank, Daniel M, Lerman, Sara, Shaw, Farnaz, Dadrass, Yue, Zhang, Wei, Liu, Man, Hung, Kevin B, Jones, and R Lor, Randall
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Male ,Surveys and Questionnaires ,Quality of Life ,Humans ,Bone Neoplasms ,Female ,Patient Reported Outcome Measures ,Prospective Studies ,Middle Aged ,Prognosis ,Follow-Up Studies ,Pain Measurement - Abstract
The prevalence of metastatic bone disease (MBD) grows each year as treatments improve. Little has been published about functional and pain outcomes in this group after surgery. Patient-Reported Outcomes Measurement Information System (PROMISBasic demographics and PROMISThe average change in physical function at week 1 was -2.5 (standard deviation [SD] = 5.4), at 2 weeks 1.7 (SD = 7.6), after 4 weeks 6.9 (SD = 10), after 6 weeks 6.4 (SD = 10.9), after 10 weeks 15.3 (SD = 3.1), and after 3 months 8.6 (SD = 7.6). The average change in pain inference at week 1 was -1.2 (SD = 7.3), at 2 weeks -2.1 (SD = 9.5), after 4 weeks -12.6 (SD = 4.5), after 6 weeks -8.3 (SD = 10.2), after 10 weeks -16.6 (SD = 4.3), and after 3 months -11.4 (SD = 8.2).PROMIS
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- 2018
12. The effect of surgical margins on outcomes for low grade MPNSTs and atypical neurofibroma
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David Viskochil, Angelica R. Putnam, Kevin B. Jones, Nicholas M. Bernthal, and R. Lor Randall
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Surgical margin ,medicine.medical_specialty ,business.industry ,General Medicine ,Disease ,medicine.disease ,Surgery ,Nerve sheath tumor ,Atypical Neurofibroma ,Oncology ,Adjuvant therapy ,Medicine ,Positive Surgical Margin ,Neurofibromatosis ,business ,Wide resection - Abstract
Author(s): Bernthal, Nicholas M; Putnam, Angelica; Jones, Kevin B; Viskochil, David; Randall, R Lor | Abstract: Background and objectivesWhile convention defines atypical neurofibroma as benign and low-grade malignant peripheral nerve sheath tumors (MPNSTs) as malignant, sparse outcomes data exist for these tumors. This study reviews clinical outcomes of surgically resected low-grade MPNST and atypical neurofibroma, focusing on the effect of surgical margins on outcome.MethodsThis study is a retrospective review of 23 patients who underwent surgical resection of a low-grade MPNST or atypical neurofibroma. Treatment characteristics of adjuvant therapy and surgical margin were noted. Endpoints of local recurrence, presence of metastatic disease, disease-specific survival, and overall survival were reviewed.ResultsEighteen of 23 patients (78%) had microscopically positive margins on the resection. Disease-specific survival was 100% for both atypical neurofibroma patients and those with low-grade MPNST, regardless of surgical margin. Local recurrence in terms of recurrence of measureable disease occurred in 2/12 (16.7%) of LGMPNST patients and 1/11 (9.1%) of atypical NF patients, all of whom had microscopically positive surgical margins.ConclusionsIn a study dedicated exclusively to "intermediate" nerve sheath tumors, no patients developed metastatic disease nor died of disease despite a high rate of microscopically positive surgical margins (78%). While positive margins did lead to increased rates of local recurrence, these data suggest that surgeons potentially can temper their zeal for negative surgical margins in the setting of low-grade MPNST and atypical neurofibroma, as surgical morbidity may be more important than a presumed survival benefit of wide resection.
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- 2014
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13. Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma: Multi-institutional analysis of 261 patients
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Ying J. Hitchcock, Sagus Sampath, R. Lor Randall, Timothy E. Schultheiss, Dennis C. Shrieve, and Jeffrey Y.C. Wong
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medicine.medical_specialty ,business.industry ,Proportional hazards model ,medicine.medical_treatment ,Soft tissue sarcoma ,Retrospective cohort study ,General Medicine ,medicine.disease ,Lower risk ,Confidence interval ,Surgery ,Radiation therapy ,Oncology ,Medicine ,Sarcoma ,business ,Survival analysis - Abstract
Background and Objective To examine the impact of adjuvant radiotherapy (RT) and surgical technique on survival in retroperitoneal soft-tissue sarcoma. Methods A retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumor registries owned by IMPAC® Medical Systems (Sunnyvale, CA). Patients who received definitive surgery with negative or microscopic-positive margins were included. Multivariate analysis was performed using the Cox proportional hazards model. Survival curves were estimated by the Kaplan–Meier method and were compared for statistical significance (P
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- 2010
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14. The effect of surgical margins on outcomes for low grade MPNSTs and atypical neurofibroma
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Nicholas M, Bernthal, Angelica, Putnam, Kevin B, Jones, David, Viskochil, and R Lor, Randall
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Adult ,Male ,Neurofibroma ,Adolescent ,Prognosis ,Survival Rate ,Young Adult ,Child, Preschool ,Humans ,Female ,Neoplasm Grading ,Neoplasm Recurrence, Local ,Child ,Neurilemmoma ,Follow-Up Studies ,Retrospective Studies - Abstract
While convention defines atypical neurofibroma as benign and low-grade malignant peripheral nerve sheath tumors (MPNSTs) as malignant, sparse outcomes data exist for these tumors. This study reviews clinical outcomes of surgically resected low-grade MPNST and atypical neurofibroma, focusing on the effect of surgical margins on outcome.This study is a retrospective review of 23 patients who underwent surgical resection of a low-grade MPNST or atypical neurofibroma. Treatment characteristics of adjuvant therapy and surgical margin were noted. Endpoints of local recurrence, presence of metastatic disease, disease-specific survival, and overall survival were reviewed.Eighteen of 23 patients (78%) had microscopically positive margins on the resection. Disease-specific survival was 100% for both atypical neurofibroma patients and those with low-grade MPNST, regardless of surgical margin. Local recurrence in terms of recurrence of measureable disease occurred in 2/12 (16.7%) of LGMPNST patients and 1/11 (9.1%) of atypical NF patients, all of whom had microscopically positive surgical margins.In a study dedicated exclusively to "intermediate" nerve sheath tumors, no patients developed metastatic disease nor died of disease despite a high rate of microscopically positive surgical margins (78%). While positive margins did lead to increased rates of local recurrence, these data suggest that surgeons potentially can temper their zeal for negative surgical margins in the setting of low-grade MPNST and atypical neurofibroma, as surgical morbidity may be more important than a presumed survival benefit of wide resection.
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- 2014
15. Does experience matter in sarcoma surgery?
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R Lor, Randall
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Humans ,Sarcoma - Published
- 2013
16. Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma: multi-institutional analysis of 261 patients
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Sagus, Sampath, Ying J, Hitchcock, Dennis C, Shrieve, R Lor, Randall, Timothy E, Schultheiss, and Jeffrey Y C, Wong
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Adult ,Aged, 80 and over ,Male ,Sarcoma ,Middle Aged ,Combined Modality Therapy ,Multivariate Analysis ,Humans ,Female ,Retroperitoneal Neoplasms ,Treatment Failure ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
To examine the impact of adjuvant radiotherapy (RT) and surgical technique on survival in retroperitoneal soft-tissue sarcoma.A retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumor registries owned by IMPAC(R) Medical Systems (Sunnyvale, CA). Patients who received definitive surgery with negative or microscopic-positive margins were included. Multivariate analysis was performed using the Cox proportional hazards model. Survival curves were estimated by the Kaplan-Meier method and were compared for statistical significance (P0.05) using the log-rank test.Two hundred sixty-one patients met inclusion criteria. The median follow-up was 59 months (range 0.2-186 months). The 5-year cause-specific survival (CSS) and local failure-free survival (LFFS) were 73% and 66%, respectively. Grade, margin status, and histology were independent predictors for CSS (P0.05). Adjuvant RT was associated with a significant improvement in LFFS over surgery alone (hazard ratio = 0.42, 95% confidence interval 0.21-0.86, P0.05). Patients receiving simple excision and RT had a 5-year LFFS of 88%, significantly higher than wide resection with or without RT (log-rank, P0.05).Adjuvant RT is associated with a lower risk of local relapse compared to surgery alone. The impact of surgical technique on adjuvant RT efficacy warrants further study.
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- 2010
17. Length of Time to Clinical Improvement After Orthopedic Oncology Surgery in Patients With Metastatic Cancer: A Multi-Institution Patient-Reported Outcome Study.
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Groundland J, Tokson JH, Hakim A, Cizik A, Blank A, Lerman D, Jones K, and Lor Randall R
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Background: Currently, there is a paucity of data that describes the length of time required to realize improvement in pain and function following surgery for patients with metastatic cancer to bone., Methods: One hundred patients with impending or completed pathologic fractures due to metastatic cancer to bone were enrolled in this prospective cohort study. Outcomes were measured with a Computer Adaptive Test of Patient Reported Outcomes for Pain Interference and Physical Function domains, to determine the time required to achieve a Minimal Clinically Important Difference (MCID) in the tested domains., Results: Eighty-one patients were included in the analysis. Thirty-two patients (39.5%) survived and completed the follow-up to 1 year, while 23 (28.4%) died before the end of the data collection. Fifty-one patients (63.0%) achieved at least a 5-point improvement in Physical Function and 59 (72.8%) achieved at least a 5-point improvement in Pain Interference. The time to achieve the MCID was 6 weeks for the Physical Function and 4 weeks for the Pain Interference domain., Conclusion: The majority of patients with impending or completed pathologic fractures due to metastatic cancer see clinically important improvements in pain and function after surgery in an average of 4 and 6 weeks, respectively., (© 2024 The Author(s). Journal of Surgical Oncology published by Wiley Periodicals LLC.)
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- 2024
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18. Intraoperative Peripheral Frozen Margin Assessment in Soft Tissue Sarcoma.
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Zeitlinger L, Chavez GM, Wilson MD, Darrow M, Canter RJ, Lor Randall R, and Thorpe SW
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Background/objectives: Intraoperative peripheral margin sampling in soft tissue sarcoma (STS) is a routine practice among musculoskeletal oncologists. Practice patterns are variable, and evidence to support it is lacking. Rates of peripheral margin sampling at our institution were analyzed in addition to its clinical utility and cost-effectiveness., Methods: Peripheral margin sampling patterns at a tertiary sarcoma center were retrospectively evaluated. Concordance between peripheral margins and final pathology was assessed using McNemar's test and κ Coefficient. Clinical outcomes were compared, and a cost-utility analysis was performed., Results: A total of 179 patients were included. 66% had peripheral margins sampled of which 23% had frozen margins analyzed. Ten patients had positive margins (5.5% of all patients; 8.4% in those with margins sampled) and R1 margins on the final tumor specimen were identified in 15 patients (8.4%). There were no R2 resections. Three patients underwent repeat surgical resection (20%). Three patients with R1 resections had negative peripheral margins sampled, suggesting falsely reassuring peripheral margins. Peripheral margin sampling averaged $5000/patient., Conclusions: Routine peripheral margin sampling in STS resection is of questionable utility with added cost. Prospective studies are warranted to determine the optimal approach to surgical margin assessment., (© 2024 Wiley Periodicals LLC.)
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- 2024
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