1. Perioperative blood transfusions and survival in resected pancreatic adenocarcinoma patients given multimodality therapy
- Author
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Shannon Hancher-Hodges, Morgan L. Bruno, Jonathan A. Wilks, Ching Wei D. Tzeng, Jose M. Soliz, Timothy E. Newhook, Matthew H.G. Katz, Naruhiko Ikoma, Jessica E. Maxwell, Jeffrey E. Lee, Elsa M. Arvide, B. Bryce Speer, Whitney L. Dewhurst, Laura R. Prakash, and Michael P. Kim
- Subjects
Male ,medicine.medical_specialty ,Blood transfusion ,medicine.medical_treatment ,Perineural invasion ,Adenocarcinoma ,Gastroenterology ,Pancreatectomy ,Internal medicine ,Pancreatic cancer ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Blood Transfusion ,Prospective Studies ,Neoadjuvant therapy ,Aged ,Retrospective Studies ,business.industry ,Hazard ratio ,General Medicine ,Perioperative ,Middle Aged ,Prognosis ,medicine.disease ,Combined Modality Therapy ,Neoadjuvant Therapy ,Pancreatic Neoplasms ,Survival Rate ,Oncology ,Pancreatic fistula ,Female ,Surgery ,business ,Carcinoma, Pancreatic Ductal ,Follow-Up Studies - Abstract
BACKGROUND AND OBJECTIVES The impact of perioperative blood transfusion (PBT) on outcomes for pancreatic ductal adenocarcinoma (PDAC) patients given multimodality therapy (MMT) remains undefined. We sought to evaluate the association of PBT with survival after PDAC resection. METHODS Pancreatectomy patients (July 2011-December 2017) who received MMT were abstracted from a prospective database. Overall survival (OS) was compared by PBT within 30 days, 24 h (24HR-BT), or 24 h until 30 days (Postop-BT). RESULTS Most (76.6%) of 312 MMT patients underwent neoadjuvant therapy (NT). Eighty-nine patients (28.5%) received PBT; 58 (18.6%) 24HR-BT, and 31 (9.9%) Postop-BT. Compared with surgery-first, NT patients received more 24HR-BTs (22.2% vs. 6.8%, p = 0.003) and PBTs overall (32.6% vs. 15.1%, p = 0.004). Overall median OS was 45 months. The association of PBT with shorter median OS appeared limited to first 24-h transfusions (34 months 24HR-BT vs. 48 months Postop-BT vs. 53 months no-PBT, p = 0.009) and was dose-dependent, with a median OS of 52 months for 0 units 24HR-BT, 35 months for 1 unit, and 25 months for ≥2 units (p = 0.004). Independent predictors of OS included node-positivity (hazard ratio [HR]: 1.93, p
- Published
- 2021
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