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Your search keyword '"Velmahos, George C."' showing total 26 results
Start Over Author "Velmahos, George C." Journal journal of surgical research
26 results on '"Velmahos, George C."'

10. Open Abdomen in Elderly Patients With Surgical Sepsis: Predictors of Mortality

Author

Proaño-Zamudio, Jefferson A., primary, Argandykov, Dias, additional, Gebran, Anthony, additional, Renne, Angela, additional, Paranjape, Charudutt N., additional, Maroney, Stephanie J., additional, Onyewadume, Louisa, additional, Kaafarani, Haytham M.A., additional, King, David R., additional, Velmahos, George C., additional, and Hwabejire, John O., additional

Published
2023
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13. Rhabdomyolysis in Severe COVID-19: Male Sex, High Body Mass Index, and Prone Positioning Confer High Risk

Author

Mokhtari, Ava K., primary, Maurer, Lydia R., additional, Christensen, Mathias A., additional, Moheb, Mohamad El, additional, Naar, Leon, additional, Alser, Osaid, additional, Gaitanidis, Apostolos, additional, Langeveld, Kimberly, additional, Kapoen, Carolijn, additional, Breen, Kerry, additional, Velmahos, George C., additional, and Kaafarani, Haytham M.A., additional

Published
2021
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20. Pharmacologic Resuscitation Promotes Survival and Attenuates Hemorrhage-Induced Activation of Extracellular Signal-Regulated Kinase 1/2

Author

Fukudome, Eugene Y., primary, Kochanek, Ashley R., additional, Li, Yongqing, additional, Smith, Eleanor J., additional, Liu, Baoling, additional, Kheirbek, Tareq, additional, Lu, Jennifer, additional, Kim, Kyuseok, additional, Hamwi, Kristopher, additional, Velmahos, George C., additional, and Alam, Hasan B., additional

Published
2010
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25. Angioembolization in Severe Pelvic Trauma is Associated with Venous Thromboembolism.

Author

Bokenkamp, Mary, Dorken Gallastegi, Ander, Brown, Tommy, Hwabejire, John O., Fawley, Jason, Mendoza, April E., Saillant, Noelle N., Fagenholz, Peter J., Kaafarani, Haytham M.A., Velmahos, George C., and Parks, Jonathan J.

Subjects
*THROMBOEMBOLISM, *VENOUS thrombosis, *BLUNT trauma, *PELVIC fractures, *PROPENSITY score matching, *PULMONARY embolism
Abstract

Management of hemorrhage from pelvic fractures is complex and requires multidisciplinary attention. Pelvic angioembolization (AE) has become a key intervention to aid in obtaining definitive hemorrhage control. We hypothesized that pelvic AE would be associated with an increased risk of venous thromboembolism (VTE). All adults (age >16) with a severe pelvic fracture (Abbreviated Injury Scale ≥ 4) secondary to a blunt traumatic mechanism in the 2017-2019 American College of Surgeons Trauma Quality Improvement Program database were included. Patients who did not receive VTE prophylaxis during their admission were excluded. Patients who underwent pelvic AE during the first 24 h of admission were compared to those who did not using propensity score matching. Matching was performed based on patient demographics, admission physiology, comorbidities, injury severity, associated injuries, other hemorrhage control procedures, and VTE prophylaxis type, and time to initiation of VTE prophylaxis. The rates of VTE (deep vein thrombosis and pulmonary embolism) were compared between the matched groups. Of 72,985 patients with a severe blunt pelvic fracture, 1887 (2.6%) underwent pelvic AE during the first 24 h of admission versus 71,098 (97.4%) who did not. Pelvic AE patients had a higher median Injury Severity Score and more often required other hemorrhage control procedures, with laparotomy being most common (24.7%). The median time to initiation of VTE prophylaxis in pelvic AE versus no pelvic AE patients was 60.1 h (interquartile range = 36.6-98.6) versus 27.7 h (interquartile range = 13.9-52.4), respectively. After propensity score matching, pelvic AE patients were more likely to develop VTE compared to no pelvic AE patients (11.8% versus 9.5%, P = 0.03). Pelvic AE for control of hemorrhage from severe pelvic fractures is associated with an increased risk of in-hospital VTE. Patients who undergo pelvic AE are especially high risk for VTE and should be started as early as safely possible on VTE prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2023
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26. A Genome-wide Association Study Reveals a Novel Susceptibility Locus for Pancreas Divisum at 3q29.

Author

Gaitanidis A, Christensen MA, Breen KA, Kambadakone AR, Joshipura ND, Fernandez-Del Castillo C, Hernandez-Barco YG, Kaafarani HMA, Velmahos GC, Farhat MR, and Fagenholz PJ

Abstract

Introduction: Pancreas divisum (PD) is a common congenital anomaly of the pancreas, but its genetic basis remains unknown. The purpose of this genome-wide association study was to identify genetic loci associated with PD., Methods: Using the Mass General Brigham Biobank, patients diagnosed with PD were identified. Quality control and imputation were performed using standard approaches. Single nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) ≥ 5% were tested for association with PD using mixed linear model-based association analysis. The significance threshold was set at 5 × 10 -8 ., Results: A total of 13,940 subjects were included, of which 251 (1.8%) were diagnosed with PD. A genetic locus in chromosome 3q29 was found to be associated with PD (lead SNP rs3850646, MAF PD  = 34.6% vs. MAF controls  = 26.4%, beta = 0.0106, P = 1.47 × 10 -8 ). The identified locus is located in the phosphatidylinositol glycan anchor biosynthesis class Xand p21 activated kinase 2genes. The heritability of PD was estimated at 27.5%. (Expression quantitative trait loci) and chromatin interaction analysis found 12 genes whose expression may be regulated by SNPs in this genomic locus., Conclusions: The results of this study suggest that a genetic locus at 3q29 is associated with PD. This locus is in the phosphatidylinositol glycan anchor biosynthesis class X and p21 activated kinase 2 genes. Twelve candidate genes were identified whose expression may be regulated by this locus. These findings may help us understand both normal and aberrant pancreatic development and may aid in clinical evaluation and genetic counseling of patients with PD and associated diseases, such as acute pancreatitis., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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